Human Gene PPP2R5B (ENST00000164133.7) from GENCODE V44
Description: Homo sapiens protein phosphatase 2 regulatory subunit B'beta (PPP2R5B), mRNA. (from RefSeq NM_006244) RefSeq Summary (NM_006244): The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000164133.7 Gencode Gene: ENSG00000068971.14 Transcript (Including UTRs) Position: hg38 chr11:64,924,689-64,934,475 Size: 9,787 Total Exon Count: 14 Strand: + Coding Region Position: hg38 chr11:64,925,735-64,933,844 Size: 8,110 Coding Exon Count: 13
ID:2A5B_HUMAN DESCRIPTION: RecName: Full=Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform; AltName: Full=PP2A B subunit isoform B'-beta; AltName: Full=PP2A B subunit isoform B56-beta; AltName: Full=PP2A B subunit isoform PR61-beta; AltName: Full=PP2A B subunit isoform R5-beta; FUNCTION: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The phosphorylated form mediates the interaction between AKT1 and PP2A phosphatase leading to dephosphorylation of AKT1 on the 'Thr-308' and 'Ser-373' residues. SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGOL1. Interacts with AKT1. INTERACTION: O96017:CHEK2; NbExp=2; IntAct=EBI-1369497, EBI-1180783; SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Highest expression in brain. INDUCTION: By retinoic acid; in neuroblastoma cell lines. SIMILARITY: Belongs to the phosphatase 2A regulatory subunit B56 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF01603 - Protein phosphatase 2A regulatory B subunit (B56 family)
ModBase Predicted Comparative 3D Structure on Q15173
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0019888 protein phosphatase regulator activity
Biological Process: GO:0001932 regulation of protein phosphorylation GO:0007165 signal transduction GO:0010469 regulation of receptor activity GO:0010976 positive regulation of neuron projection development GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO:0031334 positive regulation of protein complex assembly GO:0031952 regulation of protein autophosphorylation GO:0036498 IRE1-mediated unfolded protein response GO:0043666 regulation of phosphoprotein phosphatase activity GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway GO:0070317 negative regulation of G0 to G1 transition GO:0071158 positive regulation of cell cycle arrest GO:0071363 cellular response to growth factor stimulus
LF211192 - JP 2014500723-A/18695: Polycomb-Associated Non-Coding RNAs. MA446769 - JP 2018138019-A/18695: Polycomb-Associated Non-Coding RNAs. AK092730 - Homo sapiens cDNA FLJ35411 fis, clone SMINT2000232, highly similar to SERINE/THREONINE PROTEIN PHOSPHATASE 2A, 56 KDA REGULATORY SUBUNIT, BETA ISOFORM. AX747693 - Sequence 1218 from Patent EP1308459. BC045619 - Homo sapiens protein phosphatase 2, regulatory subunit B', beta isoform, mRNA (cDNA clone MGC:39486 IMAGE:5294756), complete cds. AB209289 - Homo sapiens mRNA for beta isoform of regulatory subunit B56, protein phosphatase 2A variant protein. JD394670 - Sequence 375694 from Patent EP1572962. JD192043 - Sequence 173067 from Patent EP1572962. JD423058 - Sequence 404082 from Patent EP1572962. L42374 - Homo sapiens protein phosphatase 2A B56-beta (PP2A) mRNA, complete cds. JD118172 - Sequence 99196 from Patent EP1572962. JD527629 - Sequence 508653 from Patent EP1572962. AB587404 - Synthetic construct DNA, clone: pF1KB5886, Homo sapiens PPP2R5B gene for protein phosphatase 2, regulatory subunit B', beta isoform, without stop codon, in Flexi system. EU446998 - Synthetic construct Homo sapiens clone IMAGE:100070135; IMAGE:100012207; FLH257504.01L protein phosphatase 2, regulatory subunit B', beta isoform (PPP2R5B) gene, encodes complete protein. Z69028 - H.sapiens mRNA for beta 2 isoform of 61 kDa regulatory subunit of PP2A. JD393225 - Sequence 374249 from Patent EP1572962. JD056767 - Sequence 37791 from Patent EP1572962. JD452645 - Sequence 433669 from Patent EP1572962. JD372535 - Sequence 353559 from Patent EP1572962. JD437147 - Sequence 418171 from Patent EP1572962. JD195760 - Sequence 176784 from Patent EP1572962. JD392248 - Sequence 373272 from Patent EP1572962. JD336542 - Sequence 317566 from Patent EP1572962. JD193872 - Sequence 174896 from Patent EP1572962. JD392042 - Sequence 373066 from Patent EP1572962. JD255936 - Sequence 236960 from Patent EP1572962. JD150405 - Sequence 131429 from Patent EP1572962. JD403512 - Sequence 384536 from Patent EP1572962. JD245141 - Sequence 226165 from Patent EP1572962. JD296588 - Sequence 277612 from Patent EP1572962. JD318663 - Sequence 299687 from Patent EP1572962. JD250180 - Sequence 231204 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04114 - Oocyte meiosis hsa04310 - Wnt signaling pathway
Reactome (by CSHL, EBI, and GO)
Protein Q15173 (Reactome details) participates in the following event(s):
R-HSA-6811454 MAPKs phosphorylate PP2A R-HSA-6811472 IER3 recruits MAPKs to PP2A-B56-beta,gamma R-HSA-195251 Assembly of the destruction complex R-HSA-389532 PP2A binds CTLA4 homodimer R-HSA-432143 PECAM-1 binds PP2A R-HSA-8857925 Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 R-HSA-201685 Beta-catenin is released from the destruction complex R-HSA-388833 Phosphorylation of CTLA-4 R-HSA-6811504 AKT1 dephosphorylation by PP2A-B56-beta,gamma R-HSA-5229343 AXIN is phosphorylated in the destruction complex R-HSA-195280 Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex R-HSA-195275 Phosphorylation of APC component of the destruction complex R-HSA-2130279 Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex R-HSA-141409 Mad1 binds kinetochore R-HSA-375302 Kinetochore capture of astral microtubules R-HSA-5666129 CDC42:GTP recruits DIAPH2-2 to kinetochores R-HSA-5666169 Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 R-HSA-388809 CTLA-4 binds B7-1/B7-2 R-HSA-195304 Association of beta-catenin with the destruction complex R-HSA-390329 Dephosphorylation of AKT by PP2A R-HSA-5672957 PP2A dephosphorylates KSR1 R-HSA-5672961 PP2A dephosphorylates inactive RAFs R-HSA-5675431 PP2A dephosphorylates RAF1 R-HSA-2130286 Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) R-HSA-141431 MAD2 associates with the Mad1 kinetochore complex R-HSA-141439 Release of activated MAD2 from kinetochores R-HSA-2467811 Separation of sister chromatids R-HSA-2467809 ESPL1 (Separase) cleaves centromeric cohesin R-HSA-5666160 AURKB phosphorylates DIAPH2-2 at kinetochores R-HSA-195287 Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 R-HSA-195318 Phosphorylation of beta-catenin at Ser45 by CK1 alpha R-HSA-195300 Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 R-HSA-195283 Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 R-HSA-141422 MAD2 converted to an inhibitory state via interaction with Mad1 R-HSA-1638821 PP2A-B56 dephosphorylates centromeric cohesin R-HSA-1638803 Phosphorylation of cohesin by PLK1 at centromeres R-HSA-2468287 CDK1 phosphorylates CDCA5 (Sororin) at centromeres R-HSA-381038 XBP1(S) activates chaperone genes R-HSA-381070 IRE1alpha activates chaperones R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-195253 Degradation of beta-catenin by the destruction complex R-HSA-389513 CTLA4 inhibitory signaling R-HSA-432142 Platelet sensitization by LDL R-HSA-5467337 APC truncation mutants have impaired AXIN binding R-HSA-5467340 AXIN missense mutants destabilize the destruction complex R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-381119 Unfolded Protein Response (UPR) R-HSA-199418 Negative regulation of the PI3K/AKT network R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-68877 Mitotic Prometaphase R-HSA-5663220 RHO GTPases Activate Formins R-HSA-195721 Signaling by WNT R-HSA-388841 Costimulation by the CD28 family R-HSA-418346 Platelet homeostasis R-HSA-4839744 truncated APC mutants destabilize the destruction complex R-HSA-4839735 AXIN mutants destabilize the destruction complex, activating WNT signaling R-HSA-4839748 AMER1 mutants destabilize the destruction complex R-HSA-201681 TCF dependent signaling in response to WNT R-HSA-5673000 RAF activation R-HSA-5675221 Negative regulation of MAPK pathway R-HSA-392499 Metabolism of proteins R-HSA-1257604 PIP3 activates AKT signaling R-HSA-5358751 S45 mutants of beta-catenin aren't phosphorylated R-HSA-5358752 T41 mutants of beta-catenin aren't phosphorylated R-HSA-5358749 S37 mutants of beta-catenin aren't phosphorylated R-HSA-5358747 S33 mutants of beta-catenin aren't phosphorylated R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2467813 Separation of Sister Chromatids R-HSA-141424 Amplification of signal from the kinetochores R-HSA-68886 M Phase R-HSA-195258 RHO GTPase Effectors R-HSA-196299 Beta-catenin phosphorylation cascade R-HSA-5339716 Misspliced GSK3beta mutants stabilize beta-catenin R-HSA-162582 Signal Transduction R-HSA-1280218 Adaptive Immune System R-HSA-109582 Hemostasis R-HSA-4791275 Signaling by WNT in cancer R-HSA-5673001 RAF/MAP kinase cascade R-HSA-9006925 Intracellular signaling by second messengers R-HSA-4839743 phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex R-HSA-68882 Mitotic Anaphase R-HSA-69618 Mitotic Spindle Checkpoint R-HSA-69278 Cell Cycle (Mitotic) R-HSA-194315 Signaling by Rho GTPases R-HSA-168256 Immune System R-HSA-5663202 Diseases of signal transduction R-HSA-5684996 MAPK1/MAPK3 signaling R-HSA-2555396 Mitotic Metaphase and Anaphase R-HSA-69620 Cell Cycle Checkpoints R-HSA-1640170 Cell Cycle R-HSA-1643685 Disease R-HSA-5683057 MAPK family signaling cascades
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