Human Gene MMP3 (ENST00000299855.10) from GENCODE V44
Description: Homo sapiens matrix metallopeptidase 3 (MMP3), mRNA. (from RefSeq NM_002422) RefSeq Summary (NM_002422): Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000299855.10 Gencode Gene: ENSG00000149968.12 Transcript (Including UTRs) Position: hg38 chr11:102,835,801-102,843,609 Size: 7,809 Total Exon Count: 10 Strand: - Coding Region Position: hg38 chr11:102,836,126-102,843,546 Size: 7,421 Coding Exon Count: 10
ID:MMP3_HUMAN DESCRIPTION: RecName: Full=Stromelysin-1; Short=SL-1; EC=3.4.24.17; AltName: Full=Matrix metalloproteinase-3; Short=MMP-3; AltName: Full=Transin-1; Flags: Precursor; FUNCTION: Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase. CATALYTIC ACTIVITY: Preferential cleavage where P1', P2' and P3' are hydrophobic residues. COFACTOR: Binds 4 calcium ions per subunit. COFACTOR: Binds 2 zinc ions per subunit. SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (Probable). DOMAIN: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. DISEASE: Defects in MMP3 are the cause of susceptibility to coronary heart disease type 6 (CHDS6) [MIM:614466]. A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries. Note=A polymorphism in the MMP3 promoter region is associated with the risk of coronary heart disease and myocardial infarction, due to lower MMP3 proteolytic activity and higher extracellular matrix deposition in atherosclerotic lesions. SIMILARITY: Belongs to the peptidase M10A family. SIMILARITY: Contains 4 hemopexin-like domains. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/mmp3/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P08254
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Protein P08254 (Reactome details) participates in the following event(s):
R-HSA-1604731 Autocatalytic activation of MMP3 R-HSA-1592371 Initial activation of proMMP3 R-HSA-1454781 MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin R-HSA-2179402 Active MMP3 can cleave pro-HBEGF to form active HBEGF R-HSA-1592297 Full activation of MMP1 R-HSA-1474197 Collagen type II degradation by MMP1,3,8,13,PRSS2 R-HSA-1564142 Collagen type IV degradation by MMP2,3,4,9,10,12 R-HSA-1564120 Collagen type VII degradation by MMP1,2,3 R-HSA-1564184 Collagen type IX degradation by MMP3,13 R-NUL-2482219 Collagen type IX degradation R-HSA-1564179 Collagen type XI degradation by MMP1,2,3,9 R-NUL-2484859 Collagen type XI degradation by MMP1,2,3,9 R-HSA-2168923 Collagen type XVIII endostatin release R-NUL-2484854 Collagen type X degradation by MMP3, 13 R-HSA-2484882 Collagen type X degradation by MMP3, 13 R-HSA-1566962 Elastin degradation by elastin-degrading extracellular proteinases R-HSA-1592362 Activation of proMMP7 by MMP3 R-HSA-1604752 Initial activation of proMMP13 by MMP3 R-HSA-2514772 Fibrillin-1 degradation by MMP3, CTSK, CTSL2 R-HSA-1566981 Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS R-HSA-2533970 NID1 degradation by MMP3, 7 R-HSA-4086205 OPN (osteopontin) degradation by MMP3, MMP7 R-HSA-1592314 HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) R-HSA-2534248 DCN (decorin) degradation by MMP2, MMP3, MMP7 R-HSA-1454843 E-cadherin degradation by MMP3, MMP7 and plasmin. R-NUL-2534162 E-cadherin strand dimer degradation by MMP3, MMP7 and Plasmin R-HSA-3791149 Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 R-HSA-3791295 Aggrecan degradation by MMP1,2,3,7,9,12,13 R-NUL-3814821 Aggrecan degradation by MMP1,2,3,7,9,12,13 R-HSA-1592436 Initial activation of proMMP9 by MMPs R-HSA-1604690 Activation of MMP9 intermediate form by MMPs R-HSA-2213200 Release of endostatin-like peptides R-HSA-1566979 Laminin-332 degradation by laminin-322 degrading extracellular proteinases R-HSA-1592389 Activation of Matrix Metalloproteinases R-HSA-2179392 EGFR Transactivation by Gastrin R-HSA-1474228 Degradation of the extracellular matrix R-HSA-6785807 Interleukin-4 and 13 signaling R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-1442490 Collagen degradation R-HSA-1474244 Extracellular matrix organization R-HSA-449147 Signaling by Interleukins R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures R-HSA-416476 G alpha (q) signalling events R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-1474290 Collagen formation R-HSA-388396 GPCR downstream signalling R-HSA-168256 Immune System R-HSA-372790 Signaling by GPCR R-HSA-162582 Signal Transduction