Human Gene KLRG1 (ENST00000356986.8) from GENCODE V44
Description: Homo sapiens killer cell lectin like receptor G1 (KLRG1), transcript variant 8, non-coding RNA. (from RefSeq NR_137428) RefSeq Summary (NM_005810): Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. [provided by RefSeq, Jun 2016]. Gencode Transcript: ENST00000356986.8 Gencode Gene: ENSG00000139187.10 Transcript (Including UTRs) Position: hg38 chr12:8,989,546-9,010,751 Size: 21,206 Total Exon Count: 5 Strand: + Coding Region Position: hg38 chr12:8,989,636-9,009,537 Size: 19,902 Coding Exon Count: 5
ID:KLRG1_HUMAN DESCRIPTION: RecName: Full=Killer cell lectin-like receptor subfamily G member 1; AltName: Full=C-type lectin domain family 15 member A; AltName: Full=ITIM-containing receptor MAFA-L; AltName: Full=MAFA-like receptor; AltName: Full=Mast cell function-associated antigen; FUNCTION: Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells. SUBUNIT: Forms monomer and homodimer; disulfide-linked (By similarity). Interacts (via ITIM motif) with PTPN11 and INPP5D (By similarity). SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. TISSUE SPECIFICITY: Expressed specifically on natural killer (NK) cells and T-cells, mainly CD8 T-cells. INDUCTION: By pathogens and viruses infections. DOMAIN: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. Upon phosphorylation of ITIM motif KLRG1 associates with the two phosphatases PTPN11 and INPP5D (By similarity). SIMILARITY: Contains 1 C-type lectin domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96E93
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Cellular Component: GO:0005886 plasma membrane GO:0016020 membrane GO:0016021 integral component of membrane GO:0043231 intracellular membrane-bounded organelle
Descriptions from all associated GenBank mRNAs
AK316337 - Homo sapiens cDNA, FLJ79236 complete cds, highly similar to Homo sapiens killer cell lectin-like receptor subfamily G, member 1 (KLRG1), mRNA. JD483973 - Sequence 464997 from Patent EP1572962. BC012621 - Homo sapiens killer cell lectin-like receptor subfamily G, member 1, mRNA (cDNA clone MGC:13660 IMAGE:4108843), complete cds. AK301367 - Homo sapiens cDNA FLJ56726 complete cds, highly similar to Homo sapiens killer cell lectin-like receptor subfamily G, member 1 (KLRG1), mRNA. AF081675 - Homo sapiens ITIM-containing receptor MAFA-L mRNA, complete cds. AF097358 - Homo sapiens mast cell function-associated antigen homolog (MAFA) mRNA, complete cds. AF034952 - Homo sapiens mast cell function-associated antigen (MAFA) mRNA, complete cds. DQ892820 - Synthetic construct clone IMAGE:100005450; FLH190021.01X; RZPDo839D0875D killer cell lectin-like receptor subfamily G, member 1 (KLRG1) gene, encodes complete protein. DQ896066 - Synthetic construct Homo sapiens clone IMAGE:100010526; FLH190017.01L; RZPDo839D0865D killer cell lectin-like receptor subfamily G, member 1 (KLRG1) gene, encodes complete protein. JD466050 - Sequence 447074 from Patent EP1572962. JD280384 - Sequence 261408 from Patent EP1572962. JD468904 - Sequence 449928 from Patent EP1572962. JD199690 - Sequence 180714 from Patent EP1572962. JD266539 - Sequence 247563 from Patent EP1572962. JD344113 - Sequence 325137 from Patent EP1572962. JD498336 - Sequence 479360 from Patent EP1572962. JD224675 - Sequence 205699 from Patent EP1572962. JD240817 - Sequence 221841 from Patent EP1572962. JD517419 - Sequence 498443 from Patent EP1572962. JD517420 - Sequence 498444 from Patent EP1572962. JD105805 - Sequence 86829 from Patent EP1572962. JD509133 - Sequence 490157 from Patent EP1572962. JD283869 - Sequence 264893 from Patent EP1572962. JD075268 - Sequence 56292 from Patent EP1572962. JD470174 - Sequence 451198 from Patent EP1572962. JD239114 - Sequence 220138 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q96E93 (Reactome details) participates in the following event(s):
R-HSA-199079 Epithelial cadherin binds to KLRG1 R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-1280218 Adaptive Immune System R-HSA-168256 Immune System
US Server
