Human Gene GRIP1 (ENST00000398016.7) from GENCODE V44
Description: Homo sapiens glutamate receptor interacting protein 1 (GRIP1), transcript variant 1, mRNA. (from RefSeq NM_021150) RefSeq Summary (NM_021150): This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000398016.7 Gencode Gene: ENSG00000155974.14 Transcript (Including UTRs) Position: hg38 chr12:66,347,431-66,678,973 Size: 331,543 Total Exon Count: 24 Strand: - Coding Region Position: hg38 chr12:66,349,019-66,678,904 Size: 329,886 Coding Exon Count: 24
ID:GRIP1_HUMAN DESCRIPTION: RecName: Full=Glutamate receptor-interacting protein 1; Short=GRIP-1; FUNCTION: May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons. SUBUNIT: Interacts with EPHA7, EPHB2, KIF5A, KIF5B, KIF5C, GRIA2, GRIA3, GRIPAP1/GRASP1, PPFIA1, PPFIA4, FRAS1, PLCD4, PTPRF and liprins-alpha. Can form homomultimers or heteromultimers with GRIP2. Forms a ternary complex with GRIA2 and CSPG4 (By similarity). Interacts with ATAD1 in an ATP-dependent manner. ATAD1-catalyzed ATP hydrolysis disrupts binding to ATAD1 and to GRIA2 and leads to AMPAR complex disassembly (By similarity). Interacts with EFNB1, EFNB3 and the C-terminal tail of PRLHR. Interacts with SLC30A9 (By similarity). SUBCELLULAR LOCATION: Cytoplasmic vesicle. Endoplasmic reticulum. Cell junction, synapse, postsynaptic cell membrane (By similarity). Note=Cytoplasmic and membrane-associated with vesicles, peri-Golgi complexes and endoplasmic reticulum. Enriched in postsynaptic plasma membrane and postsynaptic densities (By similarity). DOMAIN: PDZ 6 mediates interaction with the PDZ recognition motif of EFNB1 and EPHB2 and with the C-terminus of PPFIA1 and PPFIA4. PDZ 4 and PDZ 5 mediate interaction with the C-terminus of GRIA2 and GRIA3. PDZ 4, PDZ 5 and PDZ 6 mediate homomultimers. PDZ 7 mediates interaction with PDZ domain of GRASP1. PDZ 7 domain binds CSPG4. PDZ 6 mediates interaction with the C-terminus of liprins- alpha. PDZ 1, PDZ 2 and PDZ 3 mediate interaction with the PDZ- binding motif of FRAS1 (By similarity). PDZ 4 and PDZ 5 mediate interaction with PRLHR. SIMILARITY: Contains 7 PDZ (DHR) domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y3R0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AJ133439 - Homo sapiens mRNA for GRIP1 protein. KJ898488 - Synthetic construct Homo sapiens clone ccsbBroadEn_07882 GRIP1 gene, encodes complete protein. BC115393 - Homo sapiens glutamate receptor interacting protein 1, mRNA (cDNA clone MGC:134841 IMAGE:40053971), complete cds. BC115394 - Homo sapiens glutamate receptor interacting protein 1, mRNA (cDNA clone MGC:134842 IMAGE:40053972), complete cds. AK095519 - Homo sapiens cDNA FLJ38200 fis, clone FCBBF1000377, highly similar to Homo sapiens mRNA for GRIP1 protein. AK295565 - Homo sapiens cDNA FLJ59282 partial cds, highly similar to Glutamate receptor-interacting protein 1. AK307576 - Homo sapiens cDNA, FLJ97524. BC029871 - Homo sapiens, clone IMAGE:5169851, mRNA. JD511326 - Sequence 492350 from Patent EP1572962. JD264934 - Sequence 245958 from Patent EP1572962. JD471299 - Sequence 452323 from Patent EP1572962. JD110729 - Sequence 91753 from Patent EP1572962. JD357718 - Sequence 338742 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9Y3R0 (Reactome details) participates in the following event(s):
R-HSA-416639 Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites R-HSA-421007 Endocytosis of Ca impermeable AMPA receptors R-HSA-416985 Trafficking of GluR2-containing AMPA receptors to synapse R-HSA-416993 Trafficking of GluR2-containing AMPA receptors R-HSA-399719 Trafficking of AMPA receptors R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112315 Transmission across Chemical Synapses R-HSA-112316 Neuronal System
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