Human Gene TAOK3 (ENST00000392533.8) from GENCODE V44
Description: Homo sapiens TAO kinase 3 (TAOK3), transcript variant 2, mRNA. (from RefSeq NM_016281) RefSeq Summary (NM_016281): The protein encoded by this gene is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. The encoded protein is a member of the GCK subfamily of STE20-like kinases. [provided by RefSeq, Oct 2016]. Gencode Transcript: ENST00000392533.8 Gencode Gene: ENSG00000135090.14 Transcript (Including UTRs) Position: hg38 chr12:118,149,801-118,372,907 Size: 223,107 Total Exon Count: 21 Strand: - Coding Region Position: hg38 chr12:118,150,997-118,255,567 Size: 104,571 Coding Exon Count: 19
ID:TAOK3_HUMAN DESCRIPTION: RecName: Full=Serine/threonine-protein kinase TAO3; EC=2.7.11.1; AltName: Full=Cutaneous T-cell lymphoma-associated antigen HD-CL-09; Short=CTCL-associated antigen HD-CL-09; AltName: Full=Dendritic cell-derived protein kinase; AltName: Full=JNK/SAPK-inhibitory kinase; AltName: Full=Jun kinase-inhibitory kinase; AltName: Full=Kinase from chicken homolog A; Short=hKFC-A; AltName: Full=Thousand and one amino acid protein 3; FUNCTION: Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress- activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF). CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. SUBUNIT: Self-associates. Interacts with ERN1 and TRAF2. Interaction with TRAF2 is facilitated under ER stress conditions, such as treatment with tunicamycin, and may promote TRAF2 phosphorylation. INTERACTION: O75460:ERN1; NbExp=3; IntAct=EBI-1384100, EBI-371750; Q12933:TRAF2; NbExp=2; IntAct=EBI-1384100, EBI-355744; SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Also localized to the peripheral cell membrane. TISSUE SPECIFICITY: Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver. PTM: Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylation at Ser-324 by ATM following DNA damage is required for activation of the p38/MAPK14 stress- activated MAPK cascade. Phosphorylated by LRRK2. SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. SIMILARITY: Contains 1 protein kinase domain. SEQUENCE CAUTION: Sequence=AAN09723.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H2K8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000165 MAPK cascade GO:0000186 activation of MAPKK activity GO:0006281 DNA repair GO:0006468 protein phosphorylation GO:0006469 negative regulation of protein kinase activity GO:0006974 cellular response to DNA damage stimulus GO:0007095 mitotic G2 DNA damage checkpoint GO:0007399 nervous system development GO:0016310 phosphorylation GO:0032874 positive regulation of stress-activated MAPK cascade GO:0042981 regulation of apoptotic process GO:0043507 positive regulation of JUN kinase activity GO:0046329 negative regulation of JNK cascade GO:0046330 positive regulation of JNK cascade GO:0046777 protein autophosphorylation
US Server
