Human Gene BTBD7 (ENST00000334746.10) from GENCODE V44
  Description: Homo sapiens BTB domain containing 7 (BTBD7), transcript variant 1, mRNA. (from RefSeq NM_001002860)
Gencode Transcript: ENST00000334746.10
Gencode Gene: ENSG00000011114.15
Transcript (Including UTRs)
   Position: hg38 chr14:93,237,550-93,333,036 Size: 95,487 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg38 chr14:93,242,273-93,296,051 Size: 53,779 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:93,237,550-93,333,036)mRNA (may differ from genome)Protein (1132 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGImyGene2
neXtProtOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: BTBD7_HUMAN
DESCRIPTION: RecName: Full=BTB/POZ domain-containing protein 7;
SIMILARITY: Contains 2 BTB (POZ) domains.
SEQUENCE CAUTION: Sequence=BAA96049.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAB13946.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB13946.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact; Sequence=CAH10736.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.31 RPKM in Thyroid
Total median expression: 199.52 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -125.70323-0.389 Picture PostScript Text
3' UTR -1277.304723-0.270 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011705 - BACK
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR013069 - BTB_POZ

Pfam Domains:
PF07707 - BTB And C-terminal Kelch
PF00651 - BTB/POZ domain

ModBase Predicted Comparative 3D Structure on Q9P203
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0007275 multicellular organism development
GO:0060693 regulation of branching involved in salivary gland morphogenesis

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AB040958 - Homo sapiens KIAA1525 mRNA for KIAA1525 protein.
AK291422 - Homo sapiens cDNA FLJ76853 complete cds, highly similar to Homo sapiens BTB (POZ) domain containing 7 (BTBD7), transcriptvariant 1, mRNA.
BX248762 - human full-length cDNA 5-PRIME end of clone XCL0BB001ZA04 of Neuroblastoma of Homo sapiens (human).
BC141850 - Homo sapiens BTB (POZ) domain containing 7, mRNA (cDNA clone IMAGE:8860348), complete cds.
BC047071 - Homo sapiens BTB (POZ) domain containing 7, mRNA (cDNA clone IMAGE:5267139), complete cds.
AK001510 - Homo sapiens cDNA FLJ10648 fis, clone NT2RP2005804.
BX538231 - Homo sapiens mRNA; cDNA DKFZp686N0544 (from clone DKFZp686N0544); complete cds.
AK091287 - Homo sapiens cDNA FLJ33968 fis, clone DFNES2001096.
AK074354 - Homo sapiens cDNA FLJ23774 fis, clone HEP20420.
AK303355 - Homo sapiens cDNA FLJ57807 complete cds, highly similar to BTB/POZ domain-containing protein 7.
BC167795 - Synthetic construct Homo sapiens clone IMAGE:100068185, MGC:195802 BTB (POZ) domain containing 7 (BTBD7) mRNA, encodes complete protein.
AB385478 - Synthetic construct DNA, clone: pF1KA1525, Homo sapiens BTBD7 gene for BTB/POZ domain-containing protein 7, complete cds, without stop codon, in Flexi system.
AL049394 - Homo sapiens mRNA; cDNA DKFZp586B1819 (from clone DKFZp586B1819).
AK021953 - Homo sapiens cDNA FLJ11891 fis, clone HEMBA1007267.
JD193427 - Sequence 174451 from Patent EP1572962.
JD044973 - Sequence 25997 from Patent EP1572962.
JD407973 - Sequence 388997 from Patent EP1572962.
JD211553 - Sequence 192577 from Patent EP1572962.
JD217641 - Sequence 198665 from Patent EP1572962.
JD125191 - Sequence 106215 from Patent EP1572962.
JD177246 - Sequence 158270 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K5V7, BTBD7_HUMAN, ENST00000334746.1, ENST00000334746.2, ENST00000334746.3, ENST00000334746.4, ENST00000334746.5, ENST00000334746.6, ENST00000334746.7, ENST00000334746.8, ENST00000334746.9, KIAA1525, NM_001002860, Q69Z05, Q7Z308, Q86TS0, Q9HAA4, Q9NVM0, Q9P203, uc001ybo.1, uc001ybo.2, uc001ybo.3, uc001ybo.4, uc001ybo.5, uc001ybo.6
UCSC ID: ENST00000334746.10
RefSeq Accession: NM_001002860
Protein: Q9P203 (aka BTBD7_HUMAN)
CCDS: CCDS32146.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.