Human Gene CHRM5 (ENST00000383263.7) from GENCODE V44
Description: Homo sapiens cholinergic receptor muscarinic 5 (CHRM5), transcript variant 1, mRNA. (from RefSeq NM_012125) RefSeq Summary (NM_012125): The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, stimulation of this receptor is known to increase cyclic AMP levels. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000383263.7 Gencode Gene: ENSG00000184984.10 Transcript (Including UTRs) Position: hg38 chr15:33,968,497-34,067,458 Size: 98,962 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chr15:34,062,718-34,064,316 Size: 1,599 Coding Exon Count: 1
ID:ACM5_HUMAN DESCRIPTION: RecName: Full=Muscarinic acetylcholine receptor M5; FUNCTION: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM5 sub-subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P08912
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
