Human Gene PLA2G4F (ENST00000397272.7) from GENCODE V44
  Description: Homo sapiens phospholipase A2 group IVF (PLA2G4F), transcript variant 1, mRNA. (from RefSeq NM_213600)
Gencode Transcript: ENST00000397272.7
Gencode Gene: ENSG00000168907.13
Transcript (Including UTRs)
   Position: hg38 chr15:42,139,034-42,156,636 Size: 17,603 Total Exon Count: 20 Strand: -
Coding Region
   Position: hg38 chr15:42,141,984-42,156,549 Size: 14,566 Coding Exon Count: 20 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:42,139,034-42,156,636)mRNA (may differ from genome)Protein (849 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
PubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PA24F_HUMAN
DESCRIPTION: RecName: Full=Cytosolic phospholipase A2 zeta; Short=cPLA2-zeta; EC=3.1.1.4; AltName: Full=Phospholipase A2 group IVF;
FUNCTION: Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has higher enzyme activity for phosphatidylethanolamine than phosphatidylcholine (By similarity).
CATALYTIC ACTIVITY: Phosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate.
ENZYME REGULATION: Stimulated by cytosolic Ca(2+) (By similarity).
SUBCELLULAR LOCATION: Cytoplasm, cytosol. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Translocates to lysosomal membranes in a calcium-dependent fashion (By similarity).
DOMAIN: The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity).
SIMILARITY: Contains 1 C2 domain.
SIMILARITY: Contains 1 PLA2c domain.

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

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-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 72.46 RPKM in Skin - Not Sun Exposed (Suprapubic)
Total median expression: 216.36 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -32.2087-0.370 Picture PostScript Text
3' UTR -1154.002950-0.391 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016035 - Acyl_Trfase/lysoPLipase
IPR000008 - C2_Ca-dep
IPR008973 - C2_Ca/lipid-bd_dom_CaLB
IPR018029 - C2_membr_targeting
IPR002642 - LysoPLipase_cat_dom

Pfam Domains:
PF00168 - C2 domain
PF01735 - Lysophospholipase catalytic domain

ModBase Predicted Comparative 3D Structure on Q68DD2
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004620 phospholipase activity
GO:0004622 lysophospholipase activity
GO:0004623 phospholipase A2 activity
GO:0008970 phosphatidylcholine 1-acylhydrolase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0047498 calcium-dependent phospholipase A2 activity

Biological Process:
GO:0001516 prostaglandin biosynthetic process
GO:0006629 lipid metabolic process
GO:0006644 phospholipid metabolic process
GO:0008152 metabolic process
GO:0009395 phospholipid catabolic process
GO:0015908 fatty acid transport
GO:0016042 lipid catabolic process
GO:0036148 phosphatidylglycerol acyl-chain remodeling
GO:0036149 phosphatidylinositol acyl-chain remodeling
GO:0036150 phosphatidylserine acyl-chain remodeling
GO:0036151 phosphatidylcholine acyl-chain remodeling
GO:0036152 phosphatidylethanolamine acyl-chain remodeling
GO:0050482 arachidonic acid secretion
GO:0071236 cellular response to antibiotic
GO:0071407 cellular response to organic cyclic compound

Cellular Component:
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0031982 vesicle
GO:0032587 ruffle membrane


-  Descriptions from all associated GenBank mRNAs
  BC040920 - Homo sapiens phospholipase A2, group IVF, mRNA (cDNA clone IMAGE:5759330).
BC111481 - Homo sapiens cDNA clone IMAGE:5179082, containing frame-shift errors.
BC146648 - Homo sapiens phospholipase A2, group IVF, mRNA (cDNA clone MGC:164753 IMAGE:40147152), complete cds.
AL832972 - Homo sapiens mRNA; cDNA DKFZp666G192 (from clone DKFZp666G192).
BC035335 - Homo sapiens phospholipase A2, group IVF, mRNA (cDNA clone IMAGE:5182144), partial cds.
BC142682 - Homo sapiens phospholipase A2, group IVF, mRNA (cDNA clone MGC:164970 IMAGE:40148418), complete cds.
AK172836 - Homo sapiens cDNA FLJ23997 fis, clone HSI05269.
AK122623 - Homo sapiens cDNA FLJ16044 fis, clone CTONG1000175, highly similar to Cytosolic phospholipase A2 zeta (EC 3.1.1.4).
AK304368 - Homo sapiens cDNA FLJ57347 complete cds, highly similar to Cytosolic phospholipase A2 zeta (EC 3.1.1.4).
CR749451 - Homo sapiens mRNA; cDNA DKFZp781B229 (from clone DKFZp781B229).
BC131531 - Homo sapiens phospholipase A2, group IVF, mRNA (cDNA clone MGC:141815 IMAGE:40036909), complete cds.
JD108162 - Sequence 89186 from Patent EP1572962.
JD282259 - Sequence 263283 from Patent EP1572962.
JD183097 - Sequence 164121 from Patent EP1572962.
JD423572 - Sequence 404596 from Patent EP1572962.
JD488134 - Sequence 469158 from Patent EP1572962.
JD521624 - Sequence 502648 from Patent EP1572962.
JD077191 - Sequence 58215 from Patent EP1572962.
JD054336 - Sequence 35360 from Patent EP1572962.
JD316215 - Sequence 297239 from Patent EP1572962.
JD439371 - Sequence 420395 from Patent EP1572962.
JD248111 - Sequence 229135 from Patent EP1572962.
JD084761 - Sequence 65785 from Patent EP1572962.
JD171464 - Sequence 152488 from Patent EP1572962.
JD220751 - Sequence 201775 from Patent EP1572962.
JD418629 - Sequence 399653 from Patent EP1572962.
JD163809 - Sequence 144833 from Patent EP1572962.
JD373485 - Sequence 354509 from Patent EP1572962.
JD535735 - Sequence 516759 from Patent EP1572962.
JD229597 - Sequence 210621 from Patent EP1572962.
JD178242 - Sequence 159266 from Patent EP1572962.
JD280588 - Sequence 261612 from Patent EP1572962.
JD442448 - Sequence 423472 from Patent EP1572962.
JD484812 - Sequence 465836 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04666 - Fc gamma R-mediated phagocytosis

BioCyc Knowledge Library
LIPASYN-PWY - phospholipases

Reactome (by CSHL, EBI, and GO)

Protein Q68DD2 (Reactome details) participates in the following event(s):

R-HSA-1482612 2-acyl LPC is hydrolyzed to GPCho by PLA2[8]
R-HSA-1482685 1-acyl LPC is hydrolyzed to GPCho by PLA2[8]
R-HSA-1482862 PC is hydrolysed to 2-acyl LPC by PLA2[7]
R-HSA-1482856 PC is hydrolyzed to 1-acyl LPC by PLA2[5]
R-HSA-1482828 PE is hydrolyzed to 2-acyl LPE by PLA2[4]
R-HSA-1482884 PE is hydrolyzed to 1-acyl LPE by PLA2[2]
R-HSA-1482920 PG is hydrolyzed to 2-acyl LPG by PLA2[14]
R-HSA-1482825 PI is hydrolyzed to 1-acyl LPI by PLA2[11]
R-HSA-1482897 PS is hydrolyzed to 2-acyl LPS by PLA2[10]
R-HSA-1482771 PS is hydrolyzed to 1-acyl LPS by PLA2[9]
R-HSA-1482745 PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)
R-HSA-1482847 PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM)
R-HSA-1483115 Hydrolysis of LPC
R-HSA-1482788 Acyl chain remodelling of PC
R-HSA-1482839 Acyl chain remodelling of PE
R-HSA-1482925 Acyl chain remodelling of PG
R-HSA-1482922 Acyl chain remodelling of PI
R-HSA-1482801 Acyl chain remodelling of PS
R-HSA-1483206 Glycerophospholipid biosynthesis
R-HSA-1483257 Phospholipid metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000397272.1, ENST00000397272.2, ENST00000397272.3, ENST00000397272.4, ENST00000397272.5, ENST00000397272.6, NM_213600, PA24F_HUMAN, Q68DD2, Q6ZMC8, uc001zoz.1, uc001zoz.2, uc001zoz.3, uc001zoz.4
UCSC ID: ENST00000397272.7
RefSeq Accession: NM_213600
Protein: Q68DD2 (aka PA24F_HUMAN)
CCDS: CCDS32204.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.