ID:PA24F_HUMAN DESCRIPTION: RecName: Full=Cytosolic phospholipase A2 zeta; Short=cPLA2-zeta; EC=3.1.1.4; AltName: Full=Phospholipase A2 group IVF; FUNCTION: Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has higher enzyme activity for phosphatidylethanolamine than phosphatidylcholine (By similarity). CATALYTIC ACTIVITY: Phosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate. ENZYME REGULATION: Stimulated by cytosolic Ca(2+) (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytosol. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Translocates to lysosomal membranes in a calcium-dependent fashion (By similarity). DOMAIN: The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity). SIMILARITY: Contains 1 C2 domain. SIMILARITY: Contains 1 PLA2c domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q68DD2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.