Human Gene CLK3 (ENST00000345005.8) from GENCODE V44
Description: Homo sapiens CDC like kinase 3 (CLK3), transcript variant 2, mRNA. (from RefSeq NM_003992) RefSeq Summary (NM_003992): This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors. Two transcript variants encoding different isoforms have been found for this gene. Related pseudogenes are located on chromosomes 1 and 9. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000345005.8 Gencode Gene: ENSG00000179335.20 Transcript (Including UTRs) Position: hg38 chr15:74,608,372-74,630,201 Size: 21,830 Total Exon Count: 13 Strand: + Coding Region Position: hg38 chr15:74,619,197-74,629,883 Size: 10,687 Coding Exon Count: 12
ID:CLK3_HUMAN DESCRIPTION: RecName: Full=Dual specificity protein kinase CLK3; EC=2.7.12.1; AltName: Full=CDC-like kinase 3; FUNCTION: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. ENZYME REGULATION: Leucettine L41 inhibits its kinase activity and affects the regulation of alternative splicing mediated by phosphorylation of SR proteins. SUBCELLULAR LOCATION: Isoform 1: Nucleus. Cytoplasm (By similarity). Cytoplasmic vesicle, secretory vesicle, acrosome (By similarity). SUBCELLULAR LOCATION: Isoform 2: Nucleus speckle. Note=Co- localizes with serine- and arginine-rich (SR) proteins in the nuclear speckles. TISSUE SPECIFICITY: Endothelial cells. PTM: Autophosphorylates on all three types of residues (By similarity). SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. SIMILARITY: Contains 1 protein kinase domain. SEQUENCE CAUTION: Sequence=AAH02555.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH19881.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P49761
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
