Human Gene ST8SIA2 (ENST00000268164.8) from GENCODE V44
Description: Homo sapiens ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 (ST8SIA2), transcript variant 1, mRNA. (from RefSeq NM_006011) RefSeq Summary (NM_006011): The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). This protein is a member of glycosyltransferase family 29. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000268164.8 Gencode Gene: ENSG00000140557.12 Transcript (Including UTRs) Position: hg38 chr15:92,393,881-92,468,728 Size: 74,848 Total Exon Count: 6 Strand: + Coding Region Position: hg38 chr15:92,394,065-92,464,385 Size: 70,321 Coding Exon Count: 6
ID:SIA8B_HUMAN DESCRIPTION: RecName: Full=Alpha-2,8-sialyltransferase 8B; EC=2.4.99.-; AltName: Full=Sialyltransferase 8B; Short=SIAT8-B; AltName: Full=Sialyltransferase X; Short=STX; AltName: Full=Sialytransferase St8Sia II; Short=ST8SiaII; FUNCTION: May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression. PATHWAY: Protein modification; protein glycosylation. SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type II membrane protein (Potential). TISSUE SPECIFICITY: Highly expressed in fetal brain, kidney and heart and to a much lesser extent in adult heart and thymus. SIMILARITY: Belongs to the glycosyltransferase 29 family. WEB RESOURCE: Name=GGDB; Note=GlycoGene database; URL="http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST8SIA2"; WEB RESOURCE: Name=Functional Glycomics Gateway - GTase; Note=ST8Sia II; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_637";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00777 - Glycosyltransferase family 29 (sialyltransferase)
ModBase Predicted Comparative 3D Structure on Q92186
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001574 ganglioside biosynthetic process GO:0005975 carbohydrate metabolic process GO:0006464 cellular protein modification process GO:0006486 protein glycosylation GO:0006491 N-glycan processing GO:0007399 nervous system development GO:0009311 oligosaccharide metabolic process GO:0097503 sialylation
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa00604 - Glycosphingolipid biosynthesis - ganglio series
BioCyc Knowledge Library PWY-7434 - terminal O-glycans residues modification (via type 2 precursor disaccharide) PWY-7831 - ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide PWY-7835 - superpathway of glycosphingolipids biosynthesis PWY-7841 - neolacto-series glycosphingolipids biosynthesis
Reactome (by CSHL, EBI, and GO)
Protein Q92186 (Reactome details) participates in the following event(s):
R-HSA-422454 Polysialylation of NCAM1 R-HSA-1022133 ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans R-HSA-4084978 ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues R-HSA-419037 NCAM1 interactions R-HSA-975577 N-Glycan antennae elongation R-HSA-4085001 Sialic acid metabolism R-HSA-375165 NCAM signaling for neurite out-growth R-HSA-975576 N-glycan antennae elongation in the medial/trans-Golgi R-HSA-446219 Synthesis of substrates in N-glycan biosythesis R-HSA-422475 Axon guidance R-HSA-948021 Transport to the Golgi and subsequent modification R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-1266738 Developmental Biology R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
US Server
