Human Gene ARHGDIG (ENST00000219409.8) from GENCODE V44
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Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: GDIR3_HUMAN
DESCRIPTION: RecName: Full=Rho GDP-dissociation inhibitor 3; Short=Rho GDI 3; AltName: Full=Rho-GDI gamma;
FUNCTION: Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post- translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Primarily expressed in pancreas and brain. SIMILARITY: Belongs to the Rho GDI family.
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Primer design for this transcript
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Comparative Toxicogenomics Database (CTD)
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
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Microarray Expression Data
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Press "+" in the title bar above to open this section.
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mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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Protein Domain and Structure Information
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InterPro Domains: Graphical view of domain structure IPR014756 - Ig_E-set
IPR000406 - Rho_GDI
IPR024792 - RhoGDI_domain
Pfam Domains: PF02115 - RHO protein GDP dissociation inhibitor
ModBase Predicted Comparative 3D Structure on Q99819
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Descriptions from all associated GenBank mRNAs
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AB593111 - Homo sapiens ARHGDIG mRNA for rho GDP-dissociation inhibitor 3, complete cds, clone: HP06965-RBd09D08. BC047699 - Homo sapiens Rho GDP dissociation inhibitor (GDI) gamma, mRNA (cDNA clone MGC:51949 IMAGE:5581679), complete cds. U82532 - Homo sapiens GDI-dissociation inhibitor RhoGDIgamma mRNA, complete cds. AB590832 - Synthetic construct DNA, clone: pFN21AE0909, Homo sapiens ARHGDIG gene for Rho GDP dissociation inhibitor (GDI) gamma, without stop codon, in Flexi system. CU690464 - Synthetic construct Homo sapiens gateway clone IMAGE:100021341 5' read ARHGDIG mRNA. AF498928 - Homo sapiens Rho GDP dissociation inhibitor gamma (ARHGDIG) mRNA, complete cds. AB127078 - Homo sapiens ARHGDIG, PDIP polycistronic mRNA for Rho GDP dissociation inhibitor gamma, pancreatic protein disulfide isomerase, complete cds. JD124598 - Sequence 105622 from Patent EP1572962. JD534319 - Sequence 515343 from Patent EP1572962. JD439576 - Sequence 420600 from Patent EP1572962. JD103266 - Sequence 84290 from Patent EP1572962. JD392965 - Sequence 373989 from Patent EP1572962. JD200251 - Sequence 181275 from Patent EP1572962.
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Biochemical and Signaling Pathways
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Other Names for This Gene
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Alternate Gene Symbols: ENST00000219409.1, ENST00000219409.2, ENST00000219409.3, ENST00000219409.4, ENST00000219409.5, ENST00000219409.6, ENST00000219409.7, GDIR3_HUMAN, NM_001176, Q4TT69, Q96S29, Q99819, uc002cgm.1, uc002cgm.2, uc002cgm.3 UCSC ID: ENST00000219409.8 RefSeq Accession: NM_001176
Protein: Q99819
(aka GDIR3_HUMAN)
CCDS: CCDS10404.1
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Methods, Credits, and Use Restrictions
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Click here
for details on how this gene model was made and data restrictions if any.
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