Human Gene MRM3 (ENST00000304478.9) from GENCODE V44
Description: Homo sapiens mitochondrial rRNA methyltransferase 3 (MRM3), transcript variant 1, mRNA; nuclear gene for mitochondrial product. (from RefSeq NM_018146) RefSeq Summary (NM_018146): Efficient translation of mitochondrial-derived transcripts requires proper assembly of the large subunit of the mitochondrial ribosome. Central to the biogenesis of this large subunit is the A-loop of mitochondrial 16S rRNA, which is modified by three rRNA methyltransferases located near mtDNA nucleoids. The protein encoded by this gene methylates G(1370) of 16S rRNA, and this modification is necessary for proper ribosomal large subnit assembly. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]. Gencode Transcript: ENST00000304478.9 Gencode Gene: ENSG00000171861.11 Transcript (Including UTRs) Position: hg38 chr17:782,353-792,509 Size: 10,157 Total Exon Count: 4 Strand: + Coding Region Position: hg38 chr17:782,379-792,069 Size: 9,691 Coding Exon Count: 4
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9HC36
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AF177344 - Homo sapiens clone HC90 unknown mRNA. AK001443 - Homo sapiens cDNA FLJ10581 fis, clone NT2RP2003543, weakly similar to HYPOTHETICAL TRNA/RRNA METHYLTRANSFERASE SLR1673 (EC 2.1.1.-). AK222900 - Homo sapiens mRNA for RNA methyltransferase like 1 variant, clone: HRC02632. BC011550 - Homo sapiens RNA methyltransferase like 1, mRNA (cDNA clone MGC:19968 IMAGE:4620063), complete cds. BC050614 - Homo sapiens RNA methyltransferase like 1, mRNA (cDNA clone MGC:60073 IMAGE:5248052), complete cds. AK225128 - Homo sapiens mRNA for RNA methyltransferase like 1 variant, clone: CBL03055. CU690740 - Synthetic construct Homo sapiens gateway clone IMAGE:100021368 5' read RNMTL1 mRNA. CU679954 - Synthetic construct Homo sapiens gateway clone IMAGE:100017648 5' read RNMTL1 mRNA. AB590841 - Synthetic construct DNA, clone: pFN21AE1891, Homo sapiens RNMTL1 gene for RNA methyltransferase like 1, without stop codon, in Flexi system. HQ448718 - Synthetic construct Homo sapiens clone IMAGE:100072163; CCSB007181_01 RNA methyltransferase like 1 (RNMTL1) gene, encodes complete protein. KJ899090 - Synthetic construct Homo sapiens clone ccsbBroadEn_08484 RNMTL1 gene, encodes complete protein. KJ899091 - Synthetic construct Homo sapiens clone ccsbBroadEn_08485 RNMTL1 gene, encodes complete protein. JD289391 - Sequence 270415 from Patent EP1572962. JD368104 - Sequence 349128 from Patent EP1572962. JD060865 - Sequence 41889 from Patent EP1572962. JD373126 - Sequence 354150 from Patent EP1572962. JD456767 - Sequence 437791 from Patent EP1572962. JD475160 - Sequence 456184 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9HC36 (Reactome details) participates in the following event(s):
R-HSA-6793096 MRM3 (RNMTL1) methylates guanosine-1370 of 16S rRNA yielding 2'-O-methylguanosine-1370 R-HSA-6793080 rRNA modification in the mitochondrion R-HSA-8868766 rRNA processing in the mitochondrion R-HSA-72312 rRNA processing R-HSA-8953854 Metabolism of RNA