Human Gene MNT (ENST00000174618.5) from GENCODE V44
Description: Homo sapiens MAX network transcriptional repressor (MNT), mRNA. (from RefSeq NM_020310) RefSeq Summary (NM_020310): The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000174618.5 Gencode Gene: ENSG00000070444.15 Transcript (Including UTRs) Position: hg38 chr17:2,384,073-2,401,060 Size: 16,988 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr17:2,386,901-2,400,712 Size: 13,812 Coding Exon Count: 6
ID:MNT_HUMAN DESCRIPTION: RecName: Full=Max-binding protein MNT; AltName: Full=Class D basic helix-loop-helix protein 3; Short=bHLHd3; AltName: Full=Myc antagonist MNT; AltName: Full=Protein ROX; FUNCTION: Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'. SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer with MAX. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Contains 1 bHLH (basic helix-loop-helix) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99583
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
