Human Gene CACNG4 (ENST00000262138.4) from GENCODE V44
Description: Homo sapiens calcium voltage-gated channel auxiliary subunit gamma 4 (CACNG4), mRNA. (from RefSeq NM_014405) RefSeq Summary (NM_014405): The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. [provided by RefSeq, Dec 2010]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000262138.4 Gencode Gene: ENSG00000075461.6 Transcript (Including UTRs) Position: hg38 chr17:66,964,707-67,033,398 Size: 68,692 Total Exon Count: 4 Strand: + Coding Region Position: hg38 chr17:66,964,912-67,031,004 Size: 66,093 Coding Exon Count: 4
ID:CCG4_HUMAN DESCRIPTION: RecName: Full=Voltage-dependent calcium channel gamma-4 subunit; AltName: Full=Neuronal voltage-gated calcium channel gamma-4 subunit; AltName: Full=Transmembrane AMPAR regulatory protein gamma-4; Short=TARP gamma-4; FUNCTION: Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. SUBUNIT: The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG5, CACNG7 and CACNG8 (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00822 - PMP-22/EMP/MP20/Claudin family
ModBase Predicted Comparative 3D Structure on Q9UBN1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006811 ion transport GO:0006816 calcium ion transport GO:0019226 transmission of nerve impulse GO:0034765 regulation of ion transmembrane transport GO:0051899 membrane depolarization GO:0070588 calcium ion transmembrane transport GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
Cellular Component: GO:0005886 plasma membrane GO:0005887 integral component of plasma membrane GO:0005891 voltage-gated calcium channel complex GO:0016020 membrane GO:0016021 integral component of membrane GO:0030666 endocytic vesicle membrane GO:0032281 AMPA glutamate receptor complex GO:0036477 somatodendritic compartment
Descriptions from all associated GenBank mRNAs
AF162692 - Homo sapiens putative voltage-gated calcium channel gamma-4 subunit (CACNG4) mRNA, complete cds. AK315149 - Homo sapiens cDNA, FLJ96120, Homo sapiens calcium channel, voltage-dependent, gamma subunit 4(CACNG4), mRNA. DQ891815 - Synthetic construct clone IMAGE:100004445; FLH180200.01X; RZPDo839H04132D calcium channel, voltage-dependent, gamma subunit 4 (CACNG4) gene, encodes complete protein. DQ895000 - Synthetic construct Homo sapiens clone IMAGE:100009460; FLH180196.01L; RZPDo839H04131D calcium channel, voltage-dependent, gamma subunit 4 (CACNG4) gene, encodes complete protein. AB529113 - Synthetic construct DNA, clone: pF1KB4697, Homo sapiens CACNG4 gene for calcium channel, voltage-dependent, gamma subunit 4, without stop codon, in Flexi system. BC034532 - Homo sapiens calcium channel, voltage-dependent, gamma subunit 4, mRNA (cDNA clone MGC:24983 IMAGE:4939335), complete cds. KJ898658 - Synthetic construct Homo sapiens clone ccsbBroadEn_08052 CACNG4 gene, encodes complete protein. LF213279 - JP 2014500723-A/20782: Polycomb-Associated Non-Coding RNAs. MA448856 - JP 2018138019-A/20782: Polycomb-Associated Non-Coding RNAs. LF212469 - JP 2014500723-A/19972: Polycomb-Associated Non-Coding RNAs. MA448046 - JP 2018138019-A/19972: Polycomb-Associated Non-Coding RNAs. JD497348 - Sequence 478372 from Patent EP1572962. JD276385 - Sequence 257409 from Patent EP1572962. JD193910 - Sequence 174934 from Patent EP1572962. JD422320 - Sequence 403344 from Patent EP1572962. JD418507 - Sequence 399531 from Patent EP1572962. JD416790 - Sequence 397814 from Patent EP1572962. JD561550 - Sequence 542574 from Patent EP1572962. AK055232 - Homo sapiens cDNA FLJ30670 fis, clone FCBBF1000686. JD214549 - Sequence 195573 from Patent EP1572962. AL831834 - Homo sapiens mRNA; cDNA DKFZp547N1914 (from clone DKFZp547N1914). JD171748 - Sequence 152772 from Patent EP1572962. JD208007 - Sequence 189031 from Patent EP1572962. JD515375 - Sequence 496399 from Patent EP1572962. JD163730 - Sequence 144754 from Patent EP1572962. AL713655 - Homo sapiens mRNA; cDNA DKFZp547M1113 (from clone DKFZp547M1113). JD056070 - Sequence 37094 from Patent EP1572962. JD462994 - Sequence 444018 from Patent EP1572962. JD366908 - Sequence 347932 from Patent EP1572962. JD325058 - Sequence 306082 from Patent EP1572962. JD416874 - Sequence 397898 from Patent EP1572962. JD394051 - Sequence 375075 from Patent EP1572962. JD164020 - Sequence 145044 from Patent EP1572962. JD418470 - Sequence 399494 from Patent EP1572962. JD325787 - Sequence 306811 from Patent EP1572962. JD510927 - Sequence 491951 from Patent EP1572962. JD072920 - Sequence 53944 from Patent EP1572962. JD201159 - Sequence 182183 from Patent EP1572962. JD222498 - Sequence 203522 from Patent EP1572962. JD339845 - Sequence 320869 from Patent EP1572962. JD157837 - Sequence 138861 from Patent EP1572962. JD042433 - Sequence 23457 from Patent EP1572962. JD295285 - Sequence 276309 from Patent EP1572962. JD470638 - Sequence 451662 from Patent EP1572962. JD201126 - Sequence 182150 from Patent EP1572962. BC004504 - Homo sapiens calcium channel, voltage-dependent, gamma subunit 4, mRNA (cDNA clone IMAGE:3837002). JD327761 - Sequence 308785 from Patent EP1572962. JD551211 - Sequence 532235 from Patent EP1572962. JD120105 - Sequence 101129 from Patent EP1572962. BC032765 - Homo sapiens cDNA clone IMAGE:4148831. JD454715 - Sequence 435739 from Patent EP1572962. JD400007 - Sequence 381031 from Patent EP1572962. JD227684 - Sequence 208708 from Patent EP1572962. JD489932 - Sequence 470956 from Patent EP1572962. JD187440 - Sequence 168464 from Patent EP1572962. JD400077 - Sequence 381101 from Patent EP1572962. JD364299 - Sequence 345323 from Patent EP1572962. JD127496 - Sequence 108520 from Patent EP1572962. JD518991 - Sequence 500015 from Patent EP1572962. JD467542 - Sequence 448566 from Patent EP1572962. JD524042 - Sequence 505066 from Patent EP1572962. JD386000 - Sequence 367024 from Patent EP1572962. JD416398 - Sequence 397422 from Patent EP1572962. JD113399 - Sequence 94423 from Patent EP1572962. JD087711 - Sequence 68735 from Patent EP1572962. JD133482 - Sequence 114506 from Patent EP1572962. JD176616 - Sequence 157640 from Patent EP1572962. JD131625 - Sequence 112649 from Patent EP1572962. JD128708 - Sequence 109732 from Patent EP1572962. JD270339 - Sequence 251363 from Patent EP1572962. JD439717 - Sequence 420741 from Patent EP1572962. JD067768 - Sequence 48792 from Patent EP1572962.