Human Gene BTBD17 (ENST00000375366.4) from GENCODE V44
  Description: Homo sapiens BTB domain containing 17 (BTBD17), mRNA. (from RefSeq NM_001080466)
Gencode Transcript: ENST00000375366.4
Gencode Gene: ENSG00000204347.4
Transcript (Including UTRs)
   Position: hg38 chr17:74,356,416-74,361,868 Size: 5,453 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg38 chr17:74,356,657-74,361,819 Size: 5,163 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:74,356,416-74,361,868)mRNA (may differ from genome)Protein (478 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHGNC
HPRDLynxMalacardsMGIneXtProtPubMed
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: BTBDH_HUMAN
DESCRIPTION: RecName: Full=BTB/POZ domain-containing protein 17; AltName: Full=Galectin-3-binding protein-like; Flags: Precursor;
SUBCELLULAR LOCATION: Secreted (Potential).
SIMILARITY: Contains 1 BACK (BTB/Kelch associated) domain.
SIMILARITY: Contains 1 BTB (POZ) domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.49 RPKM in Brain - Cerebellum
Total median expression: 21.70 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -15.0049-0.306 Picture PostScript Text
3' UTR -96.40241-0.400 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011705 - BACK
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR013069 - BTB_POZ

Pfam Domains:
PF07707 - BTB And C-terminal Kelch
PF00651 - BTB/POZ domain

ModBase Predicted Comparative 3D Structure on A6NE02
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsemblWormBase 
Protein SequenceProtein SequenceProtein SequenceProtein SequenceProtein Sequence 
AlignmentAlignmentAlignmentAlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0009615 response to virus
GO:0045071 negative regulation of viral genome replication

Cellular Component:
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  BC168374 - Synthetic construct Homo sapiens clone IMAGE:100068270, MGC:195887 BTB (POZ) domain containing 17 (BTBD17) mRNA, encodes complete protein.
JD116457 - Sequence 97481 from Patent EP1572962.
JD222361 - Sequence 203385 from Patent EP1572962.
JD140505 - Sequence 121529 from Patent EP1572962.
JD026637 - Sequence 7661 from Patent EP1572962.
JD036315 - Sequence 17339 from Patent EP1572962.
JD086001 - Sequence 67025 from Patent EP1572962.
LF212471 - JP 2014500723-A/19974: Polycomb-Associated Non-Coding RNAs.
MA448048 - JP 2018138019-A/19974: Polycomb-Associated Non-Coding RNAs.
JD022741 - Sequence 3765 from Patent EP1572962.
JD033971 - Sequence 14995 from Patent EP1572962.
JD487656 - Sequence 468680 from Patent EP1572962.
JD139431 - Sequence 120455 from Patent EP1572962.
JD283491 - Sequence 264515 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NE02, BTBDH_HUMAN, ENST00000375366.1, ENST00000375366.2, ENST00000375366.3, NM_001080466, uc002jkn.1, uc002jkn.2, uc002jkn.3, uc002jkn.4
UCSC ID: ENST00000375366.4
RefSeq Accession: NM_001080466
Protein: A6NE02 (aka BTBDH_HUMAN)
CCDS: CCDS32719.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.