Human Gene PLIN4 (ENST00000301286.5) from GENCODE V44
Description: May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets (By similarity). (from UniProt Q96Q06) RefSeq Summary (NM_001367868): Members of the perilipin family, such as PLIN4, coat intracellular lipid storage droplets (Wolins et al., 2003 [PubMed 12840023]).[supplied by OMIM, Feb 2010]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Gencode Transcript: ENST00000301286.5 Gencode Gene: ENSG00000167676.5 Transcript (Including UTRs) Position: hg38 chr19:4,502,192-4,518,486 Size: 16,295 Total Exon Count: 8 Strand: - Coding Region Position: hg38 chr19:4,504,459-4,518,272 Size: 13,814 Coding Exon Count: 7
ID:PLIN4_HUMAN DESCRIPTION: RecName: Full=Perilipin-4; AltName: Full=Adipocyte protein S3-12; FUNCTION: May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets (By similarity). SUBCELLULAR LOCATION: Cell membrane (By similarity). Cytoplasm (By similarity). Lipid droplet (By similarity). Note=Nascent lipid droplet surface-associated; association with lipid droplets is triacylglycerol synthesis-dependent (By similarity). INDUCTION: Up-regulated during adipocyte differentiation. SIMILARITY: Belongs to the perilipin family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96Q06
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
