Human Gene FCER2 (ENST00000346664.9) from GENCODE V44
Description: Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen). (from UniProt P06734) RefSeq Summary (NM_002002): The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]. Gencode Transcript: ENST00000346664.9 Gencode Gene: ENSG00000104921.15 Transcript (Including UTRs) Position: hg38 chr19:7,688,776-7,702,146 Size: 13,371 Total Exon Count: 11 Strand: - Coding Region Position: hg38 chr19:7,689,193-7,699,760 Size: 10,568 Coding Exon Count: 10
ID:FCER2_HUMAN DESCRIPTION: RecName: Full=Low affinity immunoglobulin epsilon Fc receptor; AltName: Full=BLAST-2; AltName: Full=C-type lectin domain family 4 member J; AltName: Full=Fc-epsilon-RII; AltName: Full=Immunoglobulin E-binding factor; AltName: Full=Lymphocyte IgE receptor; AltName: CD_antigen=CD23; Contains: RecName: Full=Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Contains: RecName: Full=Low affinity immunoglobulin epsilon Fc receptor soluble form; FUNCTION: Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen). SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. Secreted. Note=Also exists as a soluble excreted form. PTM: N- and O-glycosylated. MISCELLANEOUS: There are two kinds of Fc receptors for IgE, which differ in both structure and function: high affinity receptors on basophils and mast cells and low affinity receptors on lymphocytes and monocytes. SIMILARITY: Contains 1 C-type lectin domain. SEQUENCE CAUTION: Sequence=AAA52433.1; Type=Erroneous gene model prediction; WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding; Note=CD23; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_221";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P06734
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LP896127 - Sequence 991 from Patent EP3253886. BC062591 - Homo sapiens Fc fragment of IgE, low affinity II, receptor for (CD23), mRNA (cDNA clone MGC:74689 IMAGE:5216918), complete cds. BC014108 - Homo sapiens Fc fragment of IgE, low affinity II, receptor for (CD23), mRNA (cDNA clone MGC:20696 IMAGE:4309266), complete cds. E01646 - cDNA encoding Fc epsilon receptor. M14766 - Human Fc-epsilon receptor CD23 antigen (IgE receptor) mRNA complete cds. BC027879 - Homo sapiens Fc fragment of IgE, low affinity II, receptor for (CD23), mRNA (cDNA clone IMAGE:5207648), with apparent retained intron. M15059 - Human Fc-epsilon receptor (IgE receptor) mRNA, complete cds (H107 epitope). JD156534 - Sequence 137558 from Patent EP1572962. AK223207 - Homo sapiens mRNA for Fc fragment of IgE, low affinity II, receptor for (CD23A) variant, clone: SPL03672. X04772 - Human mRNA for lymphocyte IgE receptor (low affinity receptor Fc epsilon R). BC064417 - Homo sapiens Fc fragment of IgE, low affinity II, receptor for (CD23), mRNA (cDNA clone IMAGE:5750404). AK310071 - Homo sapiens cDNA, FLJ17113. JD122616 - Sequence 103640 from Patent EP1572962. JD149129 - Sequence 130153 from Patent EP1572962. JD149128 - Sequence 130152 from Patent EP1572962. JD094776 - Sequence 75800 from Patent EP1572962. JD051014 - Sequence 32038 from Patent EP1572962. JD054266 - Sequence 35290 from Patent EP1572962. JD054266 - Sequence 35290 from Patent EP1572962. JD054266 - Sequence 35290 from Patent EP1572962. JD054266 - Sequence 35290 from Patent EP1572962. JD150554 - Sequence 131578 from Patent EP1572962. JD389525 - Sequence 370549 from Patent EP1572962. KJ896802 - Synthetic construct Homo sapiens clone ccsbBroadEn_06196 FCER2 gene, encodes complete protein. DQ892235 - Synthetic construct clone IMAGE:100004865; FLH184383.01X; RZPDo839F04144D Fc fragment of IgE, low affinity II, receptor for (CD23) (FCER2) gene, encodes complete protein. EU176675 - Synthetic construct Homo sapiens clone IMAGE:100011475; FLH184382.01L; RZPDo839B02255D Fc fragment of IgE, low affinity II, receptor for (CD23) (FCER2) gene, encodes complete protein. E02912 - cDNA encoding human IgE binding factor. AB463630 - Synthetic construct DNA, clone: pF1KB6461, Homo sapiens FCER2 gene for Fc fragment of IgE, without stop codon, in Flexi system. CU680780 - Synthetic construct Homo sapiens gateway clone IMAGE:100018907 5' read FCER2 mRNA. AK310707 - Homo sapiens cDNA, FLJ17749. JD177854 - Sequence 158878 from Patent EP1572962. JD051477 - Sequence 32501 from Patent EP1572962. JD445195 - Sequence 426219 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04640 - Hematopoietic cell lineage
Reactome (by CSHL, EBI, and GO)
Protein P06734 (Reactome details) participates in the following event(s):
US Server
