Human Gene FBXL12 (ENST00000247977.9) from GENCODE V44
Description: Homo sapiens F-box and leucine rich repeat protein 12 (FBXL12), transcript variant 1, mRNA. (from RefSeq NM_017703) RefSeq Summary (NM_017703): Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]. Gencode Transcript: ENST00000247977.9 Gencode Gene: ENSG00000127452.9 Transcript (Including UTRs) Position: hg38 chr19:9,810,270-9,819,079 Size: 8,810 Total Exon Count: 3 Strand: - Coding Region Position: hg38 chr19:9,810,896-9,818,813 Size: 7,918 Coding Exon Count: 3
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NXK8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004842 ubiquitin-protein transferase activity GO:0005515 protein binding
Biological Process: GO:0000209 protein polyubiquitination GO:0006511 ubiquitin-dependent protein catabolic process GO:0016567 protein ubiquitination GO:0043687 post-translational protein modification
US Server
