Human Gene AKAP8 (ENST00000269701.7) from GENCODE V44
Description: Homo sapiens A-kinase anchoring protein 8 (AKAP8), mRNA. (from RefSeq NM_005858) RefSeq Summary (NM_005858): This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011]. Gencode Transcript: ENST00000269701.7 Gencode Gene: ENSG00000105127.10 Transcript (Including UTRs) Position: hg38 chr19:15,353,385-15,379,787 Size: 26,403 Total Exon Count: 14 Strand: - Coding Region Position: hg38 chr19:15,354,915-15,379,731 Size: 24,817 Coding Exon Count: 14
ID:AKAP8_HUMAN DESCRIPTION: RecName: Full=A-kinase anchor protein 8; Short=AKAP-8; AltName: Full=A-kinase anchor protein 95 kDa; Short=AKAP 95; FUNCTION: Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II). SUBUNIT: Binds to dimeric RII-alpha regulatory subunit of PKA during mitosis. Interacts (via C-terminus) with FIGN (By similarity). SUBCELLULAR LOCATION: Nucleus matrix. Note=Associated with the nuclear matrix. Redistributed and detached from condensed chromatin during mitosis. TISSUE SPECIFICITY: Highly expressed in heart, liver, skeletal muscle, kidney and pancreas. SIMILARITY: Belongs to the AKAP95 family. SIMILARITY: Contains 2 C2H2 AKAP95-type zinc fingers.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF04988 - A-kinase anchoring protein 95 (AKAP95)
ModBase Predicted Comparative 3D Structure on O43823
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
