Human Gene IL11 (ENST00000264563.7) from GENCODE V44
Description: Homo sapiens interleukin 11 (IL11), transcript variant 1, mRNA. (from RefSeq NM_000641) RefSeq Summary (NM_000641): The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012]. Gencode Transcript: ENST00000264563.7 Gencode Gene: ENSG00000095752.7 Transcript (Including UTRs) Position: hg38 chr19:55,364,382-55,370,463 Size: 6,082 Total Exon Count: 5 Strand: - Coding Region Position: hg38 chr19:55,366,007-55,370,310 Size: 4,304 Coding Exon Count: 5
ID:IL11_HUMAN DESCRIPTION: RecName: Full=Interleukin-11; Short=IL-11; AltName: Full=Adipogenesis inhibitory factor; Short=AGIF; AltName: INN=Oprelvekin; Flags: Precursor; FUNCTION: Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. SUBCELLULAR LOCATION: Secreted. PHARMACEUTICAL: Available under the name Neumega (Wyeth). Used for the prevention of severe thrombocytopenia and the reduction of the need for platelet transfusion following myelosuppressive chemotherapy. SIMILARITY: Belongs to the IL-6 superfamily. WEB RESOURCE: Name=Neumega; Note=Clinical information on Neumega; URL="http://www.drugs.com/cdi/neumega.html"; WEB RESOURCE: Name=Wikipedia; Note=Interleukin-11 entry; URL="http://en.wikipedia.org/wiki/Interleukin_11"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il11/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P20809
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BioCarta from NCI Cancer Genome Anatomy Project h_stemPathway - Regulation of hematopoiesis by cytokines h_inflamPathway - Cytokines and Inflammatory Response h_erythPathway - Erythrocyte Differentiation Pathway
Reactome (by CSHL, EBI, and GO)
Protein P20809 (Reactome details) participates in the following event(s):
US Server
