ID:RHOB_HUMAN DESCRIPTION: RecName: Full=Rho-related GTP-binding protein RhoB; AltName: Full=Rho cDNA clone 6; Short=h6; Flags: Precursor; FUNCTION: Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells. SUBUNIT: Binds ROCK1 and ROCK2. Also binds PKN1/PRK1. Interacts with ARGGEF3, RTKN and AKAP13. INTERACTION: Q13829:TNFAIP1; NbExp=5; IntAct=EBI-602647, EBI-2505861; SUBCELLULAR LOCATION: Late endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Nucleus. Cleavage furrow. Note=Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the nuclear margin and in the nucleus. Translocates to the equatorial region before furrow formation in a ECT2-dependent manner. INDUCTION: Up-regulated by DNA damaging agents like H(2)O(2) or ionizing radiation (IR). PTM: Prenylation specifies the subcellular location of RHOB. The farnesylated form is localized to the plasma membrane while the geranylgeranylated form is localized to the endosome. MISCELLANEOUS: RHOB is one of the targets of farnesyltransferase inhibitors which are currently under investigation as cancer therapeutics. These elevate the levels of geranylgeranylated RHOB and cause mislocalization, leading to apoptosis and antineoplastic effects. SIMILARITY: Belongs to the small GTPase superfamily. Rho family. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/RHOBID42108ch2p24.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P62745
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000281 mitotic cytokinesis GO:0001525 angiogenesis GO:0006886 intracellular protein transport GO:0006915 apoptotic process GO:0007155 cell adhesion GO:0007186 G-protein coupled receptor signaling pathway GO:0007264 small GTPase mediated signal transduction GO:0007266 Rho protein signal transduction GO:0007275 multicellular organism development GO:0008333 endosome to lysosome transport GO:0010595 positive regulation of endothelial cell migration GO:0015031 protein transport GO:0030154 cell differentiation GO:0030334 regulation of cell migration GO:0030336 negative regulation of cell migration GO:0043065 positive regulation of apoptotic process GO:0045766 positive regulation of angiogenesis GO:0045786 negative regulation of cell cycle GO:0051056 regulation of small GTPase mediated signal transduction GO:0061154 endothelial tube morphogenesis GO:0070301 cellular response to hydrogen peroxide GO:0071479 cellular response to ionizing radiation
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