Human Gene SLC35F6 (ENST00000344420.10) from GENCODE V44
  Description: Homo sapiens solute carrier family 35 member F6 (SLC35F6), mRNA. (from RefSeq NM_017877)
Gencode Transcript: ENST00000344420.10
Gencode Gene: ENSG00000213699.9
Transcript (Including UTRs)
   Position: hg38 chr2:26,764,284-26,781,231 Size: 16,948 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg38 chr2:26,764,350-26,778,511 Size: 14,162 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:26,764,284-26,781,231)mRNA (may differ from genome)Protein (371 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
PubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CB018_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein C2orf18; Flags: Precursor;
SUBCELLULAR LOCATION: Lysosome membrane; Multi-pass membrane protein.
SIMILARITY: Contains 1 EamA domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: SLC35F6
Diseases sorted by gene-association score: pancreatic ductal adenocarcinoma (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 18.61 RPKM in Adrenal Gland
Total median expression: 515.93 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -26.8066-0.406 Picture PostScript Text
3' UTR -932.502720-0.343 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009262 - DUF914_euk
IPR012404 - UCP036436

Pfam Domains:
PF06027 - Solute carrier family 35

ModBase Predicted Comparative 3D Structure on Q8N357
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsembl  
Protein SequenceProtein SequenceProtein SequenceProtein Sequence  
AlignmentAlignmentAlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0022857 transmembrane transporter activity

Biological Process:
GO:0008284 positive regulation of cell proliferation
GO:0055085 transmembrane transport
GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

Cellular Component:
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  AK000562 - Homo sapiens cDNA FLJ20555 fis, clone KAT11822.
JD462010 - Sequence 443034 from Patent EP1572962.
BC028081 - Homo sapiens chromosome 2 open reading frame 18, mRNA (cDNA clone MGC:39919 IMAGE:5216816), complete cds.
BC035519 - Homo sapiens chromosome 2 open reading frame 18, mRNA (cDNA clone IMAGE:5225493).
BX647807 - Homo sapiens mRNA; cDNA DKFZp686J0896 (from clone DKFZp686J0896).
AK075164 - Homo sapiens cDNA FLJ90683 fis, clone PLACE1005927.
AK296996 - Homo sapiens cDNA FLJ55094 complete cds.
BC011013 - Homo sapiens centromere protein A, mRNA (cDNA clone IMAGE:4286607), **** WARNING: chimeric clone ****.
AK299598 - Homo sapiens cDNA FLJ59967 complete cds.
AY358820 - Homo sapiens clone DNA125164 AWTK3047 (UNQ3047) mRNA, complete cds.
AK222929 - Homo sapiens mRNA for chromosome 2 open reading frame 18 variant, clone: HRC08074.
BX648017 - Homo sapiens mRNA; cDNA DKFZp686N0996 (from clone DKFZp686N0996).
CU688388 - Synthetic construct Homo sapiens gateway clone IMAGE:100019119 5' read C2orf18 mRNA.
KJ894108 - Synthetic construct Homo sapiens clone ccsbBroadEn_03502 C2orf18 gene, encodes complete protein.
CR457243 - Homo sapiens full open reading frame cDNA clone RZPDo834E0912D for gene C2orf18, chromosome 2 open reading frame 18; complete cds, incl. stopcodon.
JD231109 - Sequence 212133 from Patent EP1572962.
JD179385 - Sequence 160409 from Patent EP1572962.
JD393637 - Sequence 374661 from Patent EP1572962.
JD079869 - Sequence 60893 from Patent EP1572962.
JD124379 - Sequence 105403 from Patent EP1572962.
BC005887 - Homo sapiens chromosome 2 open reading frame 18, mRNA (cDNA clone IMAGE:3604869), partial cds.
JD496990 - Sequence 478014 from Patent EP1572962.
JD489003 - Sequence 470027 from Patent EP1572962.
JD499601 - Sequence 480625 from Patent EP1572962.
JD225370 - Sequence 206394 from Patent EP1572962.
BC016389 - Homo sapiens chromosome 2 open reading frame 18, mRNA (cDNA clone IMAGE:3860139).
JD311850 - Sequence 292874 from Patent EP1572962.
JD081662 - Sequence 62686 from Patent EP1572962.
JD091431 - Sequence 72455 from Patent EP1572962.
JD103313 - Sequence 84337 from Patent EP1572962.
JD097655 - Sequence 78679 from Patent EP1572962.
JD425301 - Sequence 406325 from Patent EP1572962.
JD039938 - Sequence 20962 from Patent EP1572962.
JD398552 - Sequence 379576 from Patent EP1572962.
AK025889 - Homo sapiens cDNA: FLJ22236 fis, clone HRC02042.
JD082317 - Sequence 63341 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C2orf18, CB018_HUMAN, D6W543, ENST00000344420.1, ENST00000344420.2, ENST00000344420.3, ENST00000344420.4, ENST00000344420.5, ENST00000344420.6, ENST00000344420.7, ENST00000344420.8, ENST00000344420.9, NM_017877, Q53GK2, Q8N357, Q8NBX6, Q9NWX0, uc002rhp.1, uc002rhp.2, uc002rhp.3, UNQ3047/PRO9863
UCSC ID: ENST00000344420.10
RefSeq Accession: NM_017877
Protein: Q8N357 (aka CB018_HUMAN)
CCDS: CCDS1728.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.