Human Gene PREB (ENST00000260643.7) from GENCODE V44
Description: Homo sapiens prolactin regulatory element binding (PREB), transcript variant 6, non-coding RNA. (from RefSeq NR_138479) RefSeq Summary (NM_013388): This gene encodes a protein that specifically binds to a Pit1-binding element of the prolactin (PRL) promoter. This protein may act as a transcriptional regulator and is thought to be involved in some of the developmental abnormalities observed in patients with partial trisomy 2p. This gene overlaps the abhydrolase domain containing 1 (ABHD1) gene on the opposite strand. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000260643.7 Gencode Gene: ENSG00000138073.14 Transcript (Including UTRs) Position: hg38 chr2:27,130,756-27,134,636 Size: 3,881 Total Exon Count: 9 Strand: - Coding Region Position: hg38 chr2:27,131,414-27,134,421 Size: 3,008 Coding Exon Count: 9
ID:PREB_HUMAN DESCRIPTION: RecName: Full=Prolactin regulatory element-binding protein; AltName: Full=Mammalian guanine nucleotide exchange factor mSec12; FUNCTION: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription (By similarity). Guanine nucleotide exchange factor that activates SARA2. Required for the formation of COPII transport vesicles from the ER. SUBUNIT: Binds SARA2. SUBCELLULAR LOCATION: Nucleus (By similarity). Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). TISSUE SPECIFICITY: Ubiquitous. SIMILARITY: Contains 3 WD repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9HCU5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003677 DNA binding GO:0005085 guanyl-nucleotide exchange factor activity GO:0005090 Sar guanyl-nucleotide exchange factor activity GO:0005096 GTPase activator activity GO:0005515 protein binding GO:0051020 GTPase binding
Biological Process: GO:0003400 regulation of COPII vesicle coating GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006888 ER to Golgi vesicle-mediated transport GO:0009306 protein secretion GO:0015031 protein transport GO:0016192 vesicle-mediated transport GO:0032527 protein exit from endoplasmic reticulum GO:0036498 IRE1-mediated unfolded protein response GO:0043547 positive regulation of GTPase activity GO:0048208 COPII vesicle coating GO:0050790 regulation of catalytic activity
US Server
