Human Gene CRIM1 (ENST00000280527.7) from GENCODE V44
Description: Homo sapiens cysteine rich transmembrane BMP regulator 1 (CRIM1), mRNA. (from RefSeq NM_016441) RefSeq Summary (NM_016441): This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. The encoded protein may play a role in tissue development though interactions with members of the transforming growth factor beta family, such as bone morphogenetic proteins. [provided by RefSeq, Nov 2010]. Gencode Transcript: ENST00000280527.7 Gencode Gene: ENSG00000150938.10 Transcript (Including UTRs) Position: hg38 chr2:36,355,778-36,551,135 Size: 195,358 Total Exon Count: 17 Strand: + Coding Region Position: hg38 chr2:36,356,293-36,548,701 Size: 192,409 Coding Exon Count: 17
ID:CRIM1_HUMAN DESCRIPTION: RecName: Full=Cysteine-rich motor neuron 1 protein; Short=CRIM-1; AltName: Full=Cysteine-rich repeat-containing protein S52; Contains: RecName: Full=Processed cysteine-rich motor neuron 1 protein; Flags: Precursor; FUNCTION: May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface. SUBUNIT: Interacts with BMP4 and BMP7. SUBCELLULAR LOCATION: Processed cysteine-rich motor neuron 1 protein: Secreted. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Expressed in pancreas, kidney, skeletal muscle, lung, placenta, brain, heart, spleen, liver and small intestine. Expressed in blood vessels (at protein level). PTM: N-glycosylated. SIMILARITY: Contains 4 antistasin-like domains. SIMILARITY: Contains 1 IGFBP N-terminal domain. SIMILARITY: Contains 6 VWFC domains. SEQUENCE CAUTION: Sequence=BAD92376.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF02822 - Antistasin family PF00093 - von Willebrand factor type C domain
ModBase Predicted Comparative 3D Structure on Q9NZV1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
