Human Gene MEIS1 (ENST00000272369.14) from GENCODE V44
Description: Homo sapiens Meis homeobox 1 (MEIS1), mRNA. (from RefSeq NM_002398) RefSeq Summary (NM_002398): Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000272369.14 Gencode Gene: ENSG00000143995.20 Transcript (Including UTRs) Position: hg38 chr2:66,435,125-66,573,869 Size: 138,745 Total Exon Count: 13 Strand: + Coding Region Position: hg38 chr2:66,435,857-66,569,108 Size: 133,252 Coding Exon Count: 12
ID:MEIS1_HUMAN DESCRIPTION: RecName: Full=Homeobox protein Meis1; FUNCTION: Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias. SUBUNIT: Interacts with the N-terminal region of PBX1 to form a heterodimer which binds DNA including a cAMP-responsive sequence in CYP17. Also forms heterodimers with PBX2. Forms heterotrimers with PBX1 or PBX2 and a number of HOX proteins including HOXA9, HOXD4 and HOXD9 where it acts as a non-DNA-binding partner. Also forms heterotrimers with PBX1 and HOX proteins including HOXD9 and HOXD10 where PBX1 is the non-DNA-binding partner. INTERACTION: P16220:CREB1; NbExp=9; IntAct=EBI-1210694, EBI-711855; P14921:ETS1; NbExp=2; IntAct=EBI-1210694, EBI-913209; SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Expressed at low level in normal immunohepatopoietic tissues, including the fetal liver. Expressed in a subset of myeloid leukemia cell lines, with the highest expression seen in those with a megakaryocytic-erythroid phenotype. Also expressed at high levels in the cerebellum. DISEASE: Defects in MEIS1 could be a cause of susceptibility to restless legs syndrome type 7 (RLS7) [MIM:612853]. Restless legs syndrome (RLS) is a neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation. SIMILARITY: Belongs to the TALE/MEIS homeobox family. SIMILARITY: Contains 1 homeobox DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O00470
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AL832770 - Homo sapiens mRNA; cDNA DKFZp686A197 (from clone DKFZp686A197). BC043503 - Homo sapiens Meis homeobox 1, mRNA (cDNA clone MGC:49924 IMAGE:5531644), complete cds. BC036511 - Homo sapiens Meis homeobox 1, mRNA (cDNA clone IMAGE:5266491), with apparent retained intron. AK314949 - Homo sapiens cDNA, FLJ95861, highly similar to Homo sapiens Meis1, myeloid ecotropic viral integration site 1homolog (mouse) (MEIS1), mRNA. U85707 - Human leukemogenic homolog protein (MEIS1) mRNA, complete cds. AB527915 - Synthetic construct DNA, clone: pF1KB0940, Homo sapiens MEIS1 gene for Meis homeobox protein 1, without stop codon, in Flexi system. AK297817 - Homo sapiens cDNA FLJ52704 complete cds, highly similar to Homeobox protein Meis1. AK297109 - Homo sapiens cDNA FLJ54698 complete cds, highly similar to Homeobox protein Meis1. AK098174 - Homo sapiens cDNA FLJ40855 fis, clone TRACH2016317, highly similar to HOMEOBOX PROTEIN MEIS1. JD557727 - Sequence 538751 from Patent EP1572962. JD345763 - Sequence 326787 from Patent EP1572962. LF209007 - JP 2014500723-A/16510: Polycomb-Associated Non-Coding RNAs. MA444584 - JP 2018138019-A/16510: Polycomb-Associated Non-Coding RNAs. JD113502 - Sequence 94526 from Patent EP1572962. JD116026 - Sequence 97050 from Patent EP1572962. JD284896 - Sequence 265920 from Patent EP1572962. JD046604 - Sequence 27628 from Patent EP1572962. JD316142 - Sequence 297166 from Patent EP1572962. JD251366 - Sequence 232390 from Patent EP1572962. JD372578 - Sequence 353602 from Patent EP1572962. JD290329 - Sequence 271353 from Patent EP1572962. JD044614 - Sequence 25638 from Patent EP1572962. JD232787 - Sequence 213811 from Patent EP1572962. JD295923 - Sequence 276947 from Patent EP1572962. JD268780 - Sequence 249804 from Patent EP1572962. JD044322 - Sequence 25346 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O00470 (Reactome details) participates in the following event(s):
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5619507 Activation of HOX genes during differentiation R-HSA-1266738 Developmental Biology