Human Gene TMEM182 (ENST00000409173.5) from GENCODE V44
  Description: Homo sapiens transmembrane protein 182 (TMEM182), transcript variant 3, mRNA. (from RefSeq NM_001321344)
Gencode Transcript: ENST00000409173.5
Gencode Gene: ENSG00000170417.16
Transcript (Including UTRs)
   Position: hg38 chr2:102,736,911-102,817,420 Size: 80,510 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg38 chr2:102,758,471-102,814,968 Size: 56,498 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:102,736,911-102,817,420)mRNA (may differ from genome)Protein (186 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCLynxMGIPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: B8ZZ71_HUMAN
DESCRIPTION: SubName: Full=Transmembrane protein 182;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 17.81 RPKM in Heart - Atrial Appendage
Total median expression: 65.48 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -58.00185-0.314 Picture PostScript Text
3' UTR -595.802452-0.243 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026763 - TMEM182

ModBase Predicted Comparative 3D Structure on B8ZZ71
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  LP896175 - Sequence 1039 from Patent EP3253886.
AL832688 - Homo sapiens mRNA; cDNA DKFZp313E1134 (from clone DKFZp313E1134).
AK054856 - Homo sapiens cDNA FLJ30294 fis, clone BRACE2003078.
BC107694 - Homo sapiens transmembrane protein 182, mRNA (cDNA clone IMAGE:4667189), partial cds.
BC073844 - Homo sapiens transmembrane protein 182, mRNA (cDNA clone IMAGE:3447048), partial cds.
AY358262 - Homo sapiens clone DNA179765 RLNI6974 (UNQ6974) mRNA, complete cds.
CR936735 - Homo sapiens mRNA; cDNA DKFZp779K1556 (from clone DKFZp779K1556).
CR936732 - Homo sapiens mRNA; cDNA DKFZp779M1870 (from clone DKFZp779M1870).
CR936731 - Homo sapiens mRNA; cDNA DKFZp779G1758 (from clone DKFZp779G1758).
AK129862 - Homo sapiens cDNA FLJ26352 fis, clone HRT04809.
BC130306 - Homo sapiens transmembrane protein 182, mRNA (cDNA clone MGC:163178 IMAGE:40146337), complete cds.
BC130308 - Homo sapiens transmembrane protein 182, mRNA (cDNA clone MGC:163180 IMAGE:40146339), complete cds.
HQ258113 - Synthetic construct Homo sapiens clone IMAGE:100072422 transmembrane protein 182 (TMEM182) gene, encodes complete protein.
KJ900136 - Synthetic construct Homo sapiens clone ccsbBroadEn_09530 TMEM182 gene, encodes complete protein.
AB528840 - Synthetic construct DNA, clone: pF1KE0472, Homo sapiens TMEM182 gene for transmembrane protein 182, without stop codon, in Flexi system.
AM392547 - Synthetic construct Homo sapiens clone IMAGE:100002779 for hypothetical protein (FLJ30294 gene).
AM393449 - Synthetic construct Homo sapiens clone IMAGE:100002720 for hypothetical protein (FLJ30294 gene).
AM393130 - Synthetic construct Homo sapiens clone IMAGE:100002969 for hypothetical protein (FLJ30294 gene).
AM392690 - Synthetic construct Homo sapiens clone IMAGE:100002721 for hypothetical protein (FLJ30294 gene).
AM392776 - Synthetic construct Homo sapiens clone IMAGE:100002781 for hypothetical protein (FLJ30294 gene).
AM392786 - Synthetic construct Homo sapiens clone IMAGE:100002782 for hypothetical protein (FLJ30294 gene).
AM392877 - Synthetic construct Homo sapiens clone IMAGE:100002780 for hypothetical protein (FLJ30294 gene).
BC020898 - Homo sapiens transmembrane protein 182, mRNA (cDNA clone IMAGE:4715037), complete cds.
KJ903762 - Synthetic construct Homo sapiens clone ccsbBroadEn_13156 TMEM182 gene, encodes complete protein.
JD061364 - Sequence 42388 from Patent EP1572962.
JD511901 - Sequence 492925 from Patent EP1572962.
JD374079 - Sequence 355103 from Patent EP1572962.
JD139625 - Sequence 120649 from Patent EP1572962.
JD184857 - Sequence 165881 from Patent EP1572962.
JD330700 - Sequence 311724 from Patent EP1572962.
JD050483 - Sequence 31507 from Patent EP1572962.
JD531903 - Sequence 512927 from Patent EP1572962.
JD279463 - Sequence 260487 from Patent EP1572962.
JD239107 - Sequence 220131 from Patent EP1572962.
JD088327 - Sequence 69351 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B8ZZ71, B8ZZ71_HUMAN, ENST00000409173.1, ENST00000409173.2, ENST00000409173.3, ENST00000409173.4, NM_001321344, uc002tcc.1, uc002tcc.2, uc002tcc.3, uc002tcc.4, uc002tcc.5
UCSC ID: ENST00000409173.5
RefSeq Accession: NM_001321344
Protein: B8ZZ71 CCDS: CCDS82489.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.