Human Gene NCKAP5 (ENST00000409261.6) from GENCODE V44
  Description: Homo sapiens NCK associated protein 5 (NCKAP5), transcript variant 1, mRNA. (from RefSeq NM_207363)
Gencode Transcript: ENST00000409261.6
Gencode Gene: ENSG00000176771.18
Transcript (Including UTRs)
   Position: hg38 chr2:132,671,788-133,568,463 Size: 896,676 Total Exon Count: 20 Strand: -
Coding Region
   Position: hg38 chr2:132,673,289-133,517,526 Size: 844,238 Coding Exon Count: 18 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:132,671,788-133,568,463)mRNA (may differ from genome)Protein (1909 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMGIneXtProtOMIM
PubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: NCKP5_HUMAN
DESCRIPTION: RecName: Full=Nck-associated protein 5; Short=NAP-5; AltName: Full=Peripheral clock protein;
SUBUNIT: Interacts with the SH3-containing region of the adapter protein Nck.
TISSUE SPECIFICITY: Expressed in fetal and adult brain, leukocytes and fetal fibroblasts.
CAUTION: It is uncertain whether Met-1 or Met-26 is the initiator.
SEQUENCE CAUTION: Sequence=BAA22433.1; Type=Frameshift; Positions=856, 877, 920, 926, 957, 967; Sequence=BAC85920.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: NCKAP5
Diseases sorted by gene-association score: hypersomnia (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.24 RPKM in Lung
Total median expression: 23.00 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -108.10377-0.287 Picture PostScript Text
3' UTR -330.601501-0.220 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026163 - Nckap5l

ModBase Predicted Comparative 3D Structure on O14513
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD Ensembl  
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0008150 biological_process

Cellular Component:
GO:0005575 cellular_component


-  Descriptions from all associated GenBank mRNAs
  BC172401 - Synthetic construct Homo sapiens clone IMAGE:100069095, MGC:199106 Nck-associated protein 5 (NAP5) mRNA, encodes complete protein.
AK092189 - Homo sapiens cDNA FLJ34870 fis, clone NT2NE2014651.
AX747399 - Sequence 924 from Patent EP1308459.
BC110831 - Homo sapiens Nck-associated protein 5, mRNA (cDNA clone IMAGE:6067662), partial cds.
AK057980 - Homo sapiens cDNA FLJ25251 fis, clone STM03603.
AK124659 - Homo sapiens cDNA FLJ42668 fis, clone BRAMY2020270.
AY946007 - Homo sapiens peripheral clock protein 1 (ERIH1) mRNA, complete cds.
AY946008 - Homo sapiens peripheral clock protein 2 (ERIH2) mRNA, complete cds.
AB005217 - Homo sapiens mRNA for Nck-associated protein NAP5, partial cds.

-  Other Names for This Gene
  Alternate Gene Symbols: B8ZZL0, ENST00000409261.1, ENST00000409261.2, ENST00000409261.3, ENST00000409261.4, ENST00000409261.5, ERIH, NAP5, NCKP5_HUMAN, NM_207363, O14513, Q29SS9, Q29ST0, Q2NL90, Q6ZVE2, Q8NAS3, uc002ttp.1, uc002ttp.2, uc002ttp.3, uc002ttp.4
UCSC ID: ENST00000409261.6
RefSeq Accession: NM_207363
Protein: O14513 (aka NCKP5_HUMAN)
CCDS: CCDS46418.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.