ID:RPGF4_HUMAN DESCRIPTION: RecName: Full=Rap guanine nucleotide exchange factor 4; AltName: Full=Exchange factor directly activated by cAMP 2; AltName: Full=Exchange protein directly activated by cAMP 2; Short=EPAC 2; AltName: Full=cAMP-regulated guanine nucleotide exchange factor II; Short=cAMP-GEFII; FUNCTION: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA- independent exocytosis through interaction with RIMS2 (By similarity). SUBUNIT: Interacts with RIMS1 and RIMS2. Probably part of a complex with RIMS2 and GTP-activated RAB3A (By similarity). SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein (By similarity). TISSUE SPECIFICITY: Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels. DOMAIN: The N-terminal nucleotide phosphate binding region cAMP 1 has a much lower affinity for cAMP as compared to cAMP 2. DOMAIN: The DEP domain is involved in membrane localization independent from regulation by cAMP (By similarity). SIMILARITY: Contains 2 cyclic nucleotide-binding domains. SIMILARITY: Contains 1 DEP domain. SIMILARITY: Contains 1 N-terminal Ras-GEF domain. SIMILARITY: Contains 1 Ras-GEF domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00027 - Cyclic nucleotide-binding domain PF00610 - Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PF00788 - Ras association (RalGDS/AF-6) domain PF00617 - RasGEF domain PF00618 - RasGEF N-terminal motif
ModBase Predicted Comparative 3D Structure on Q8WZA2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
