Human Gene KLF7 (ENST00000309446.11) from GENCODE V44
  Description: Homo sapiens Kruppel like factor 7 (KLF7), transcript variant 1, mRNA. (from RefSeq NM_003709)
RefSeq Summary (NM_003709): The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].
Gencode Transcript: ENST00000309446.11
Gencode Gene: ENSG00000118263.16
Transcript (Including UTRs)
   Position: hg38 chr2:207,074,137-207,165,948 Size: 91,812 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg38 chr2:207,081,213-207,165,568 Size: 84,356 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:207,074,137-207,165,948)mRNA (may differ from genome)Protein (302 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGencode
GeneCardsHGNCHPRDLynxMGIneXtProt
OMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: KLF7_HUMAN
DESCRIPTION: RecName: Full=Krueppel-like factor 7; AltName: Full=Ubiquitous krueppel-like factor;
FUNCTION: Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1 recognition sequence.
SUBCELLULAR LOCATION: Nucleus (Probable).
TISSUE SPECIFICITY: Ubiquitous and highly expressed in brain and spinal cord in the adult, and in kidney and brain in the embryo.
DOMAIN: The acidic N-terminal part may favor interaction with the basic domain of transcription factors.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 3 C2H2-type zinc fingers.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: KLF7
Diseases sorted by gene-association score: bruxism (9)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 10.59 RPKM in Adipose - Subcutaneous
Total median expression: 258.74 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -110.80380-0.292 Picture PostScript Text
3' UTR -1969.027076-0.278 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

ModBase Predicted Comparative 3D Structure on O75840
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsembl  
Protein SequenceProtein SequenceProtein SequenceProtein Sequence  
AlignmentAlignmentAlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0003713 transcription coactivator activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048813 dendrite morphogenesis

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  BX537890 - Homo sapiens mRNA; cDNA DKFZp313F0536 (from clone DKFZp313F0536); complete cds.
AK027371 - Homo sapiens cDNA FLJ14465 fis, clone MAMMA1000388, highly similar to Krueppel-like factor 7.
BC012919 - Homo sapiens Kruppel-like factor 7 (ubiquitous), mRNA (cDNA clone MGC:21308 IMAGE:4509200), complete cds.
AB015132 - Homo sapiens UKLF mRNA for ubiquitous Kruppel like factor, complete cds.
AK297312 - Homo sapiens cDNA FLJ54523 complete cds, highly similar to Krueppel-like factor 7.
HF546205 - Homo sapiens mRNA for Kruppel-like factor 7 (ubiquitous), splice variant 1 (KLF7 gene).
HF546206 - Homo sapiens mRNA for Kruppel-like factor 7 (ubiquitous), splice variant 2 (KLF7 gene).
CR542112 - Homo sapiens full open reading frame cDNA clone RZPDo834H0737D for gene KLF7, Kruppel-like factor 7 (ubiquitous); complete cds, incl. stopcodon.
AK314439 - Homo sapiens cDNA, FLJ95237, Homo sapiens Kruppel-like factor 7 (ubiquitous) (KLF7), mRNA.
AB463823 - Synthetic construct DNA, clone: pF1KB8289, Homo sapiens KLF7 gene for Kruppel-like factor 7, without stop codon, in Flexi system.
KJ901889 - Synthetic construct Homo sapiens clone ccsbBroadEn_11283 KLF7 gene, encodes complete protein.
DQ578906 - Homo sapiens piRNA piR-47018, complete sequence.
AK000969 - Homo sapiens cDNA FLJ10107 fis, clone HEMBA1002583.
JD435301 - Sequence 416325 from Patent EP1572962.
JD539256 - Sequence 520280 from Patent EP1572962.
JD097319 - Sequence 78343 from Patent EP1572962.
JD098952 - Sequence 79976 from Patent EP1572962.
JD412934 - Sequence 393958 from Patent EP1572962.
JD050240 - Sequence 31264 from Patent EP1572962.
JD193141 - Sequence 174165 from Patent EP1572962.
JD216313 - Sequence 197337 from Patent EP1572962.
JD150601 - Sequence 131625 from Patent EP1572962.
JD464722 - Sequence 445746 from Patent EP1572962.
JD325336 - Sequence 306360 from Patent EP1572962.
JD224177 - Sequence 205201 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RB03, ENST00000309446.1, ENST00000309446.10, ENST00000309446.2, ENST00000309446.3, ENST00000309446.4, ENST00000309446.5, ENST00000309446.6, ENST00000309446.7, ENST00000309446.8, ENST00000309446.9, KLF7_HUMAN, NM_003709, O75840, uc002vbz.1, uc002vbz.2, uc002vbz.3, uc002vbz.4, UKLF
UCSC ID: ENST00000309446.11
RefSeq Accession: NM_003709
Protein: O75840 (aka KLF7_HUMAN)
CCDS: CCDS2373.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.