Human Gene SDCBP2 (ENST00000360779.4) from GENCODE V44
Description: Homo sapiens FKBP1A-SDCBP2 readthrough (NMD candidate) (FKBP1A-SDCBP2), long non-coding RNA. (from RefSeq NR_037661) RefSeq Summary (NM_080489): The protein encoded by this gene contains two class II PDZ domains. PDZ domains facilitate protein-protein interactions by binding to the cytoplasmic C-terminus of transmembrane proteins, and PDZ-containing proteins mediate cell signaling and the organization of protein complexes. The encoded protein binds to phosphatidylinositol 4, 5-bisphosphate (PIP2) and plays a role in nuclear PIP2 organization and cell division. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Read-through transcription also exists between this gene and the upstream FKBP1A (FK506 binding protein 1A, 12kDa) gene, as represented in GeneID:100528031. [provided by RefSeq, Sep 2011]. Gencode Transcript: ENST00000360779.4 Gencode Gene: ENSG00000125775.15 Transcript (Including UTRs) Position: hg38 chr20:1,309,909-1,329,139 Size: 19,231 Total Exon Count: 9 Strand: - Coding Region Position: hg38 chr20:1,310,441-1,320,416 Size: 9,976 Coding Exon Count: 8
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00595 - PDZ domain (Also known as DHR or GLGF)
ModBase Predicted Comparative 3D Structure on Q9H190
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0005546 phosphatidylinositol-4,5-bisphosphate binding GO:0008022 protein C-terminus binding GO:0008289 lipid binding GO:0042802 identical protein binding GO:0042803 protein homodimerization activity GO:0046982 protein heterodimerization activity
Biological Process: GO:0007399 nervous system development GO:0008283 cell proliferation GO:0035556 intracellular signal transduction GO:0046907 intracellular transport
US Server
