Human Gene MACROD2 (ENST00000217246.8) from GENCODE V44
Description: Homo sapiens mono-ADP ribosylhydrolase 2 (MACROD2), transcript variant 1, mRNA. (from RefSeq NM_080676) RefSeq Summary (NM_080676): The protein encoded by this gene is a deacetylase involved in removing ADP-ribose from mono-ADP-ribosylated proteins. The encoded protein has been shown to translocate from the nucleus to the cytoplasm upon DNA damage. [provided by RefSeq, May 2017]. Gencode Transcript: ENST00000217246.8 Gencode Gene: ENSG00000172264.19 Transcript (Including UTRs) Position: hg38 chr20:13,995,369-16,053,197 Size: 2,057,829 Total Exon Count: 17 Strand: + Coding Region Position: hg38 chr20:13,995,764-16,049,876 Size: 2,054,113 Coding Exon Count: 17
ID:MACD2_HUMAN DESCRIPTION: RecName: Full=O-acetyl-ADP-ribose deacetylase MACROD2; EC=3.5.1.-; AltName: Full=MACRO domain-containing protein 2; FUNCTION: Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=107 uM for O-acetyl-ADP-ribose; SIMILARITY: Contains 1 Macro domain. SEQUENCE CAUTION: Sequence=BAD18504.1; Type=Frameshift; Positions=151;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on A1Z1Q3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006974 cellular response to DNA damage stimulus GO:0007420 brain development GO:0042278 purine nucleoside metabolic process GO:0051725 protein de-ADP-ribosylation
US Server
