Human Gene CFAP298 (ENST00000290155.8) from GENCODE V44
Description: Homo sapiens cilia and flagella associated protein 298 (CFAP298), transcript variant 1, mRNA. (from RefSeq NM_021254) RefSeq Summary (NM_021254): This gene encodes a protein that plays a critical role in dynein arm assembly and motile cilia function. Mutations in this gene result in primary ciliary dyskinesia. Naturally occuring readthrough transcription occurs from this locus to the downstream t-complex 10 like (TCP10L) gene. [provided by RefSeq, Apr 2017]. Gencode Transcript: ENST00000290155.8 Gencode Gene: ENSG00000159079.19 Transcript (Including UTRs) Position: hg38 chr21:32,599,354-32,612,377 Size: 13,024 Total Exon Count: 7 Strand: - Coding Region Position: hg38 chr21:32,601,863-32,612,243 Size: 10,381 Coding Exon Count: 7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF11069 - Protein of unknown function (DUF2870)
ModBase Predicted Comparative 3D Structure on P57076
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
