Human Gene GART (ENST00000381839.7) from GENCODE V44
Description: Homo sapiens phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase (GART), transcript variant 4, mRNA. (from RefSeq NM_001136006) RefSeq Summary (NM_001136006): The protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000381839.7 Gencode Gene: ENSG00000159131.17 Transcript (Including UTRs) Position: hg38 chr21:33,503,931-33,542,861 Size: 38,931 Total Exon Count: 22 Strand: - Coding Region Position: hg38 chr21:33,504,124-33,539,315 Size: 35,192 Coding Exon Count: 21
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P22102
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000166 nucleotide binding GO:0003824 catalytic activity GO:0004637 phosphoribosylamine-glycine ligase activity GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity GO:0004644 phosphoribosylglycinamide formyltransferase activity GO:0005524 ATP binding GO:0016740 transferase activity GO:0016742 hydroxymethyl-, formyl- and related transferase activity GO:0016874 ligase activity GO:0046872 metal ion binding
Biological Process: GO:0003360 brainstem development GO:0006164 purine nucleotide biosynthetic process GO:0006189 'de novo' IMP biosynthetic process GO:0006544 glycine metabolic process GO:0008152 metabolic process GO:0009058 biosynthetic process GO:0009113 purine nucleobase biosynthetic process GO:0009156 ribonucleoside monophosphate biosynthetic process GO:0009168 purine ribonucleoside monophosphate biosynthetic process GO:0010033 response to organic substance GO:0010035 response to inorganic substance GO:0021549 cerebellum development GO:0021987 cerebral cortex development GO:0046654 tetrahydrofolate biosynthetic process
US Server
