Human Gene TFF3 (ENST00000518498.3) from GENCODE V44
Description: Homo sapiens trefoil factor 3 (TFF3), mRNA. (from RefSeq NM_003226) RefSeq Summary (NM_003226): Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Gencode Transcript: ENST00000518498.3 Gencode Gene: ENSG00000160180.17 Transcript (Including UTRs) Position: hg38 chr21:42,311,667-42,315,409 Size: 3,743 Total Exon Count: 3 Strand: - Coding Region Position: hg38 chr21:42,312,256-42,315,374 Size: 3,119 Coding Exon Count: 3
ID:TFF3_HUMAN DESCRIPTION: RecName: Full=Trefoil factor 3; AltName: Full=Intestinal trefoil factor; Short=hITF; AltName: Full=Polypeptide P1.B; Short=hP1.B; Flags: Precursor; FUNCTION: Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen). SUBUNIT: Monomer. Homodimer; disulfide-linked. SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, apical lamina. TISSUE SPECIFICITY: Expressed in goblet cells of the intestines and colon (at protein level). Expressed by goblet cells of small and large intestinal epithelia and also by the uterus. SIMILARITY: Contains 1 P-type (trefoil) domain. SEQUENCE CAUTION: Sequence=AAH17859.1; Type=Erroneous initiation; Sequence=AAL28111.1; Type=Erroneous initiation; Sequence=BAA95531.1; Type=Erroneous initiation; Sequence=BAB13731.1; Type=Erroneous initiation; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/TFF3ID265.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q07654
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
