Human Gene OSM (ENST00000215781.3) from GENCODE V44
Description: Homo sapiens oncostatin M (OSM), transcript variant 1, mRNA. (from RefSeq NM_020530) RefSeq Summary (NM_020530): This gene encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophage colony stimulating factor in endothelial cells. This gene and the related gene, leukemia inhibitory factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]. Gencode Transcript: ENST00000215781.3 Gencode Gene: ENSG00000099985.4 Transcript (Including UTRs) Position: hg38 chr22:30,262,829-30,266,851 Size: 4,023 Total Exon Count: 3 Strand: - Coding Region Position: hg38 chr22:30,263,883-30,266,799 Size: 2,917 Coding Exon Count: 3
ID:ONCM_HUMAN DESCRIPTION: RecName: Full=Oncostatin-M; Short=OSM; Flags: Precursor; FUNCTION: Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity). SUBCELLULAR LOCATION: Secreted. PTM: Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory activity. SIMILARITY: Belongs to the LIF/OSM family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P13725
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
