Human Gene OSBP2 (ENST00000332585.11) from GENCODE V44
Description: Homo sapiens oxysterol binding protein 2 (OSBP2), transcript variant 1, mRNA. (from RefSeq NM_030758) RefSeq Summary (NM_030758): The protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2013]. Gencode Transcript: ENST00000332585.11 Gencode Gene: ENSG00000184792.16 Transcript (Including UTRs) Position: hg38 chr22:30,694,874-30,907,813 Size: 212,940 Total Exon Count: 14 Strand: + Coding Region Position: hg38 chr22:30,694,910-30,906,339 Size: 211,430 Coding Exon Count: 14
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF01237 - Oxysterol-binding protein PF00169 - PH domain
ModBase Predicted Comparative 3D Structure on Q969R2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK296525 - Homo sapiens cDNA FLJ55561 complete cds, highly similar to Oxysterol-binding protein 2. AK131374 - Homo sapiens cDNA FLJ16431 fis, clone BRACE3009127, highly similar to Homo sapiens oxysterol binding protein 2 (OSBP2). AF323731 - Homo sapiens OSBP-related protein 4 mRNA, complete cds. AK097581 - Homo sapiens cDNA FLJ40262 fis, clone TESTI2025846, highly similar to Homo sapiens OSBP-related protein 4 mRNA. AK294007 - Homo sapiens cDNA FLJ60102 complete cds, highly similar to Oxysterol-binding protein 2. BC118914 - Homo sapiens oxysterol binding protein 2, mRNA (cDNA clone MGC:134823 IMAGE:40037933), complete cds. AB051451 - Homo sapiens KIAA1664 mRNA for KIAA1664 protein. AB384622 - Synthetic construct DNA, clone: pF1KA1664, Homo sapiens OSBP2 gene for oxysterol-binding protein 2, complete cds, without stop codon, in Flexi system. AF288741 - Homo sapiens oxysterol binding protein 2 (OSBP2) mRNA, complete cds. AK093196 - Homo sapiens cDNA FLJ35877 fis, clone TESTI2008425, moderately similar to OXYSTEROL-BINDING PROTEIN. AX747984 - Sequence 1509 from Patent EP1308459. AK296354 - Homo sapiens cDNA FLJ59707 complete cds, highly similar to Oxysterol-binding protein 2. AK300323 - Homo sapiens cDNA FLJ60349 complete cds, highly similar to Oxysterol-binding protein 2. BC004340 - Homo sapiens cDNA clone IMAGE:3632045. BC018025 - Homo sapiens cDNA clone IMAGE:4289132, partial cds. JD189455 - Sequence 170479 from Patent EP1572962.
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