Human Gene YWHAH (ENST00000248975.6) from GENCODE V44
Description: Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta (YWHAH), mRNA. (from RefSeq NM_003405) RefSeq Summary (NM_003405): This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009]. Gencode Transcript: ENST00000248975.6 Gencode Gene: ENSG00000128245.15 Transcript (Including UTRs) Position: hg38 chr22:31,944,535-31,957,603 Size: 13,069 Total Exon Count: 2 Strand: + Coding Region Position: hg38 chr22:31,944,734-31,956,792 Size: 12,059 Coding Exon Count: 2
ID:1433F_HUMAN DESCRIPTION: RecName: Full=14-3-3 protein eta; AltName: Full=Protein AS1; FUNCTION: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. SUBUNIT: Homodimer (By similarity). Interacts with many nuclear hormone receptors and cofactors including AR, ESR1, ESR2, MC2R, NR3C1, NRIP1, PPARBP and THRA. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with ARHGEF28 and CDK16 (By similarity). Weakly interacts with CDKN1B. Interacts with GAB2. Interacts with KCNK18 in a phosphorylation- dependent manner. Interacts with SAMSN1 (By similarity). Interacts with the 'Ser-241' phosphorylated form of PDPK1. INTERACTION: O94921:CDK14; NbExp=3; IntAct=EBI-306940, EBI-1043945; O60565:GREM1; NbExp=5; IntAct=EBI-306940, EBI-944395; Q14678-2:KANK1; NbExp=3; IntAct=EBI-306940, EBI-6173812; Q7KZI7:MARK2; NbExp=6; IntAct=EBI-306940, EBI-516560; P27448:MARK3; NbExp=4; IntAct=EBI-306940, EBI-707595; Q96L34:MARK4; NbExp=6; IntAct=EBI-306940, EBI-302319; Q8TEW0:PARD3; NbExp=6; IntAct=EBI-306940, EBI-81968; Q9NPB6:PARD6A; NbExp=2; IntAct=EBI-306940, EBI-81876; Q9BYG5:PARD6B; NbExp=2; IntAct=EBI-306940, EBI-295391; Q9BYG4:PARD6G; NbExp=2; IntAct=EBI-306940, EBI-295417; P41743:PRKCI; NbExp=3; IntAct=EBI-306940, EBI-286199; P04049:RAF1; NbExp=2; IntAct=EBI-306940, EBI-365996; TISSUE SPECIFICITY: Expressed mainly in the brain and present in other tissues albeit at lower levels. SIMILARITY: Belongs to the 14-3-3 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q04917
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002028 regulation of sodium ion transport GO:0006713 glucocorticoid catabolic process GO:0006886 intracellular protein transport GO:0021762 substantia nigra development GO:0042921 glucocorticoid receptor signaling pathway GO:0045664 regulation of neuron differentiation GO:0045893 positive regulation of transcription, DNA-templated GO:0048167 regulation of synaptic plasticity GO:0050774 negative regulation of dendrite morphogenesis GO:0061024 membrane organization GO:0086010 membrane depolarization during action potential GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:2000649 regulation of sodium ion transmembrane transporter activity
BioCarta from NCI Cancer Genome Anatomy Project h_cdc25Pathway - cdc25 and chk1 Regulatory Pathway in response to DNA damage h_aktPathway - AKT Signaling Pathway h_hdacPathway - Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK) h_pgc1aPathway - Regulation of PGC-1a h_MITRPathway - Signal Dependent Regulation of Myogenesis by Corepressor MITR h_rbPathway - RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage h_achPathway - Role of nicotinic acetylcholine receptors in the regulation of apoptosis h_g2Pathway - Cell Cycle: G2/M Checkpoint h_badPathway - Regulation of BAD phosphorylation h_igf1rPathway - Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation h_plk3Pathway - Regulation of cell cycle progression by Plk3
Reactome (by CSHL, EBI, and GO)
Protein Q04917 (Reactome details) participates in the following event(s):
US Server
