Human Gene TAFA5 (ENST00000358295.9) from GENCODE V44
  Description: Homo sapiens TAFA chemokine like family member 5 (TAFA5), transcript variant 2, mRNA. (from RefSeq NM_015381)
RefSeq Summary (NM_015381): This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Sep 2013].
Gencode Transcript: ENST00000358295.9
Gencode Gene: ENSG00000219438.9
Transcript (Including UTRs)
   Position: hg38 chr22:48,576,306-48,751,932 Size: 175,627 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg38 chr22:48,576,481-48,749,847 Size: 173,367 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:48,576,306-48,751,932)mRNA (may differ from genome)Protein (125 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHPRD
MGIneXtProtOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: F19A5_HUMAN
DESCRIPTION: RecName: Full=Protein FAM19A5; AltName: Full=Chemokine-like protein TAFA-5;
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
SUBCELLULAR LOCATION: Isoform 2: Secreted.
TISSUE SPECIFICITY: Isoform 2 is brain-specific.
SIMILARITY: Belongs to the FAM19/TAFA family.
SEQUENCE CAUTION: Sequence=AAD20061.1; Type=Erroneous initiation; Sequence=AAH39396.2; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 44.46 RPKM in Nerve - Tibial
Total median expression: 528.31 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -93.70175-0.535 Picture PostScript Text
3' UTR -778.802085-0.374 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR020350 - Chemokine-like_FAM19A2

Pfam Domains:
PF12020 - TAFA family

ModBase Predicted Comparative 3D Structure on Q7Z5A7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005576 extracellular region
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC039396 - Homo sapiens family with sequence similarity 19 (chemokine (C-C motif)-like), member A5, mRNA (cDNA clone MGC:44558 IMAGE:5299791), complete cds.
AF131851 - Homo sapiens clone 25003 mRNA sequence, partial cds.
KJ902375 - Synthetic construct Homo sapiens clone ccsbBroadEn_11769 FAM19A5 gene, encodes complete protein.
AK125256 - Homo sapiens cDNA FLJ43266 fis, clone IMR322002110, highly similar to Protein FAM19A5 precursor.
AK123443 - Homo sapiens cDNA FLJ41449 fis, clone BRSTN2007000, highly similar to Protein FAM19A5 precursor.
AY325118 - Homo sapiens TAFA5 mRNA, complete cds.
AY358847 - Homo sapiens clone DNA173024 QLLK5208 (UNQ5208) mRNA, complete cds.
JD386536 - Sequence 367560 from Patent EP1572962.
JD101021 - Sequence 82045 from Patent EP1572962.
JD487662 - Sequence 468686 from Patent EP1572962.
JD076178 - Sequence 57202 from Patent EP1572962.
JD527970 - Sequence 508994 from Patent EP1572962.
JD392986 - Sequence 374010 from Patent EP1572962.
JD424279 - Sequence 405303 from Patent EP1572962.
JD467104 - Sequence 448128 from Patent EP1572962.
JD161367 - Sequence 142391 from Patent EP1572962.
JD547375 - Sequence 528399 from Patent EP1572962.
JD226992 - Sequence 208016 from Patent EP1572962.
JD521285 - Sequence 502309 from Patent EP1572962.
JD131655 - Sequence 112679 from Patent EP1572962.
JD178380 - Sequence 159404 from Patent EP1572962.
JD520543 - Sequence 501567 from Patent EP1572962.
JD062685 - Sequence 43709 from Patent EP1572962.
JD506672 - Sequence 487696 from Patent EP1572962.
JD561530 - Sequence 542554 from Patent EP1572962.
JD385360 - Sequence 366384 from Patent EP1572962.
JD234766 - Sequence 215790 from Patent EP1572962.
JD525541 - Sequence 506565 from Patent EP1572962.
JD519179 - Sequence 500203 from Patent EP1572962.
JD093474 - Sequence 74498 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NII9, B0QZ13, B0QZ14, B0QZ15, ENST00000358295.1, ENST00000358295.2, ENST00000358295.3, ENST00000358295.4, ENST00000358295.5, ENST00000358295.6, ENST00000358295.7, ENST00000358295.8, F19A5_HUMAN, FAM19A5, NM_015381, O95902, Q5H9C4, Q6UWC9, Q7Z5A7, Q8IXR8, uc003bio.1, uc003bio.2, uc003bio.3, uc003bio.4, uc003bio.5, uc003bio.6, UNQ5208/PRO34524
UCSC ID: ENST00000358295.9
RefSeq Accession: NM_015381
Protein: Q7Z5A7 (aka F19A5_HUMAN)
CCDS: CCDS46729.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.