Human Gene PPP2R3A (ENST00000264977.8) from GENCODE V44
Description: Homo sapiens protein phosphatase 2 regulatory subunit B''alpha (PPP2R3A), transcript variant 1, mRNA. (from RefSeq NM_002718) RefSeq Summary (NM_002718): This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Jun 2010]. Gencode Transcript: ENST00000264977.8 Gencode Gene: ENSG00000073711.11 Transcript (Including UTRs) Position: hg38 chr3:135,965,728-136,147,894 Size: 182,167 Total Exon Count: 14 Strand: + Coding Region Position: hg38 chr3:136,001,499-136,145,166 Size: 143,668 Coding Exon Count: 13
ID:P2R3A_HUMAN DESCRIPTION: RecName: Full=Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha; AltName: Full=PP2A subunit B isoform PR72/PR130; AltName: Full=PP2A subunit B isoform R3 isoform; AltName: Full=PP2A subunit B isoforms B''-PR72/PR130; AltName: Full=PP2A subunit B isoforms B72/B130; AltName: Full=Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B; FUNCTION: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. INTERACTION: Q969G9:NKD1; NbExp=3; IntAct=EBI-949210, EBI-1538217; TISSUE SPECIFICITY: Expressed in heart, brain, placenta, lung, muscle and kidney. SIMILARITY: Contains 2 EF-hand domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q06190
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
