ID:OSTA_HUMAN DESCRIPTION: RecName: Full=Organic solute transporter subunit alpha; Short=OST-alpha; AltName: Full=Solute carrier family 51 subunit alpha; FUNCTION: Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. SUBUNIT: Interacts with SLC51B. The Ost-alpha/Ost-beta complex is a heterodimer composed of alpha (SLC51A) and beta (SLC51B) subunit (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Note=Transported from the endoplasmic reticulum to the plasma membrane once interacting with SLC51B (By similarity). Mainly restricted to the lateral and basal membranes of ileal enterocytes. TISSUE SPECIFICITY: Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat. INDUCTION: Positively regulated via NR1H4/FXR in adrenal gland, kidney and intestine. SIMILARITY: Belongs to the OST-alpha family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q86UW1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0015125 bile acid transmembrane transporter activity GO:0022857 transmembrane transporter activity GO:0042803 protein homodimerization activity GO:0046982 protein heterodimerization activity
Biological Process: GO:0015721 bile acid and bile salt transport GO:0032782 bile acid secretion GO:0055085 transmembrane transport GO:0071702 organic substance transport
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