Human Gene DCK (ENST00000286648.10) from GENCODE V44
Description: Homo sapiens deoxycytidine kinase (DCK), mRNA. (from RefSeq NM_000788) RefSeq Summary (NM_000788): Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000286648.10 Gencode Gene: ENSG00000156136.10 Transcript (Including UTRs) Position: hg38 chr4:70,993,649-71,030,914 Size: 37,266 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr4:70,993,836-71,029,378 Size: 35,543 Coding Exon Count: 7
ID:DCK_HUMAN DESCRIPTION: RecName: Full=Deoxycytidine kinase; Short=dCK; EC=2.7.1.74; FUNCTION: Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents. CATALYTIC ACTIVITY: NTP + deoxycytidine = NDP + dCMP. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=6.2 uM for deoxycytidine (dC); KM=15.5 uM for cytarabine (araC); KM=22 uM for gemcitabine (dC); SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Nucleus. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity). Phosphorylated and activated in vitro upon phosphorylation at Ser-74 by CSNK1D/CK1. SIMILARITY: Belongs to the DCK/DGK family. CAUTION: Was shown to be phosphorylated and activated by CSNK1D/CK1 in vitro but probably not in vivo (PubMed:20637175).
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P27707
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK303292 - Homo sapiens cDNA FLJ51425 complete cds, highly similar to Deoxycytidine kinase (EC 2.7.1.74). AK313523 - Homo sapiens cDNA, FLJ94081, Homo sapiens deoxycytidine kinase (DCK), mRNA. JD024804 - Sequence 5828 from Patent EP1572962. BC103764 - Homo sapiens deoxycytidine kinase, mRNA (cDNA clone MGC:117410 IMAGE:6472612), complete cds. JD036186 - Sequence 17210 from Patent EP1572962. M60527 - Human deoxycytidine kinase mRNA, complete cds. BC114617 - Homo sapiens deoxycytidine kinase, mRNA (cDNA clone MGC:138632 IMAGE:40032871), complete cds. JD415546 - Sequence 396570 from Patent EP1572962. JF806429 - Homo sapiens deoxynucleoside kinase mRNA, complete cds. CR541876 - Homo sapiens full open reading frame cDNA clone RZPDo834D0233D for gene DCK, deoxycytidine kinase; complete cds, without stopcodon. BT019941 - Homo sapiens deoxycytidine kinase mRNA, complete cds. BT019942 - Homo sapiens deoxycytidine kinase mRNA, complete cds. KJ891031 - Synthetic construct Homo sapiens clone ccsbBroadEn_00425 DCK gene, encodes complete protein. KJ896691 - Synthetic construct Homo sapiens clone ccsbBroadEn_06085 DCK gene, encodes complete protein. KR711858 - Synthetic construct Homo sapiens clone CCSBHm_00031396 DCK (DCK) mRNA, encodes complete protein. KR711859 - Synthetic construct Homo sapiens clone CCSBHm_00031397 DCK (DCK) mRNA, encodes complete protein. KR711860 - Synthetic construct Homo sapiens clone CCSBHm_00031398 DCK (DCK) mRNA, encodes complete protein. CR536527 - Homo sapiens full open reading frame cDNA clone RZPDo834F0322D for gene DCK, deoxycytidine kinase; complete cds, incl. stopcodon. JD474624 - Sequence 455648 from Patent EP1572962. JD546878 - Sequence 527902 from Patent EP1572962. JD280364 - Sequence 261388 from Patent EP1572962. JD563628 - Sequence 544652 from Patent EP1572962. JD316993 - Sequence 298017 from Patent EP1572962. JD313861 - Sequence 294885 from Patent EP1572962. JD509015 - Sequence 490039 from Patent EP1572962. JD566636 - Sequence 547660 from Patent EP1572962. JD279797 - Sequence 260821 from Patent EP1572962. JD185586 - Sequence 166610 from Patent EP1572962. MA873464 - JP 2018536436-A/5300: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873465 - JP 2018536436-A/5301: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873466 - JP 2018536436-A/5302: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873468 - JP 2018536436-A/5304: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873469 - JP 2018536436-A/5305: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873470 - JP 2018536436-A/5306: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873471 - JP 2018536436-A/5307: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873472 - JP 2018536436-A/5308: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873473 - JP 2018536436-A/5309: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873474 - JP 2018536436-A/5310: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873475 - JP 2018536436-A/5311: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873476 - JP 2018536436-A/5312: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873477 - JP 2018536436-A/5313: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873478 - JP 2018536436-A/5314: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873479 - JP 2018536436-A/5315: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873480 - JP 2018536436-A/5316: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873481 - JP 2018536436-A/5317: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873482 - JP 2018536436-A/5318: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873483 - JP 2018536436-A/5319: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873484 - JP 2018536436-A/5320: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873485 - JP 2018536436-A/5321: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873486 - JP 2018536436-A/5322: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873544 - JP 2018536436-A/5380: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873545 - JP 2018536436-A/5381: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873546 - JP 2018536436-A/5382: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873547 - JP 2018536436-A/5383: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873548 - JP 2018536436-A/5384: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873555 - JP 2018536436-A/5391: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873556 - JP 2018536436-A/5392: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873557 - JP 2018536436-A/5393: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873558 - JP 2018536436-A/5394: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873559 - JP 2018536436-A/5395: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873560 - JP 2018536436-A/5396: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873568 - JP 2018536436-A/5404: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873569 - JP 2018536436-A/5405: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873570 - JP 2018536436-A/5406: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873571 - JP 2018536436-A/5407: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873572 - JP 2018536436-A/5408: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873573 - JP 2018536436-A/5409: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873574 - JP 2018536436-A/5410: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873580 - JP 2018536436-A/5416: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873581 - JP 2018536436-A/5417: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873582 - JP 2018536436-A/5418: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873583 - JP 2018536436-A/5419: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873584 - JP 2018536436-A/5420: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873585 - JP 2018536436-A/5421: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873589 - JP 2018536436-A/5425: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873590 - JP 2018536436-A/5426: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873591 - JP 2018536436-A/5427: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873592 - JP 2018536436-A/5428: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873595 - JP 2018536436-A/5431: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873596 - JP 2018536436-A/5432: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873597 - JP 2018536436-A/5433: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873598 - JP 2018536436-A/5434: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873599 - JP 2018536436-A/5435: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873600 - JP 2018536436-A/5436: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873601 - JP 2018536436-A/5437: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873602 - JP 2018536436-A/5438: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873603 - JP 2018536436-A/5439: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873604 - JP 2018536436-A/5440: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873605 - JP 2018536436-A/5441: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873607 - JP 2018536436-A/5443: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873609 - JP 2018536436-A/5445: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873613 - JP 2018536436-A/5449: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873614 - JP 2018536436-A/5450: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873615 - JP 2018536436-A/5451: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873617 - JP 2018536436-A/5453: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873618 - JP 2018536436-A/5454: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873619 - JP 2018536436-A/5455: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873620 - JP 2018536436-A/5456: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595876 - KR 1020180133840-A/5300: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595877 - KR 1020180133840-A/5301: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595878 - KR 1020180133840-A/5302: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595880 - KR 1020180133840-A/5304: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595881 - KR 1020180133840-A/5305: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595882 - KR 1020180133840-A/5306: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595883 - KR 1020180133840-A/5307: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595884 - KR 1020180133840-A/5308: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595885 - KR 1020180133840-A/5309: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595886 - KR 1020180133840-A/5310: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595887 - KR 1020180133840-A/5311: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595888 - KR 1020180133840-A/5312: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595889 - KR 1020180133840-A/5313: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595890 - KR 1020180133840-A/5314: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595891 - KR 1020180133840-A/5315: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595892 - KR 1020180133840-A/5316: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595893 - KR 1020180133840-A/5317: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595894 - KR 1020180133840-A/5318: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595895 - KR 1020180133840-A/5319: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595896 - KR 1020180133840-A/5320: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595897 - KR 1020180133840-A/5321: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595898 - KR 1020180133840-A/5322: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595956 - KR 1020180133840-A/5380: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595957 - KR 1020180133840-A/5381: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595958 - KR 1020180133840-A/5382: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595959 - KR 1020180133840-A/5383: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595960 - KR 1020180133840-A/5384: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595967 - KR 1020180133840-A/5391: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595968 - KR 1020180133840-A/5392: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595969 - KR 1020180133840-A/5393: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595970 - KR 1020180133840-A/5394: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595971 - KR 1020180133840-A/5395: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595972 - KR 1020180133840-A/5396: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595980 - KR 1020180133840-A/5404: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595981 - KR 1020180133840-A/5405: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595982 - KR 1020180133840-A/5406: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595983 - KR 1020180133840-A/5407: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595984 - KR 1020180133840-A/5408: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595985 - KR 1020180133840-A/5409: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595986 - KR 1020180133840-A/5410: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595992 - KR 1020180133840-A/5416: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595993 - KR 1020180133840-A/5417: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595994 - KR 1020180133840-A/5418: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595995 - KR 1020180133840-A/5419: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595996 - KR 1020180133840-A/5420: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY595997 - KR 1020180133840-A/5421: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596001 - KR 1020180133840-A/5425: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596002 - KR 1020180133840-A/5426: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596003 - KR 1020180133840-A/5427: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596004 - KR 1020180133840-A/5428: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596007 - KR 1020180133840-A/5431: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596008 - KR 1020180133840-A/5432: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596009 - KR 1020180133840-A/5433: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596010 - KR 1020180133840-A/5434: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596011 - KR 1020180133840-A/5435: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596012 - KR 1020180133840-A/5436: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596013 - KR 1020180133840-A/5437: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596014 - KR 1020180133840-A/5438: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596015 - KR 1020180133840-A/5439: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596016 - KR 1020180133840-A/5440: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596017 - KR 1020180133840-A/5441: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596019 - KR 1020180133840-A/5443: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596021 - KR 1020180133840-A/5445: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596025 - KR 1020180133840-A/5449: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596026 - KR 1020180133840-A/5450: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596027 - KR 1020180133840-A/5451: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596029 - KR 1020180133840-A/5453: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596030 - KR 1020180133840-A/5454: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596031 - KR 1020180133840-A/5455: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596032 - KR 1020180133840-A/5456: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa00230 - Purine metabolism hsa00240 - Pyrimidine metabolism