Human Gene UNC5C (ENST00000453304.6) from GENCODE V44
Description: Homo sapiens unc-5 netrin receptor C (UNC5C), mRNA. (from RefSeq NM_003728) RefSeq Summary (NM_003728): This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000453304.6 Gencode Gene: ENSG00000182168.16 Transcript (Including UTRs) Position: hg38 chr4:95,162,504-95,548,973 Size: 386,470 Total Exon Count: 16 Strand: - Coding Region Position: hg38 chr4:95,169,234-95,548,857 Size: 379,624 Coding Exon Count: 16
ID:UNC5C_HUMAN DESCRIPTION: RecName: Full=Netrin receptor UNC5C; AltName: Full=Protein unc-5 homolog 3; AltName: Full=Protein unc-5 homolog C; Flags: Precursor; FUNCTION: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity). SUBUNIT: Interacts with the cytoplasmic part of DCC (By similarity). SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity). TISSUE SPECIFICITY: Mainly expressed in brain. Also expressed in kidney. Not expressed in developing or adult lung. PTM: Phosphorylated on different cytoplasmic tyrosine residues. Phosphorylation of Tyr-568 leads to an interaction with PTPN11 phosphatase, suggesting that its activity is regulated by phosphorylation/dephosphorylation. Tyrosine phosphorylation is netrin-dependent (By similarity). PTM: Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis (By similarity). MISCELLANEOUS: Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidney cancers. SIMILARITY: Belongs to the unc-5 family. SIMILARITY: Contains 1 death domain. SIMILARITY: Contains 1 Ig-like (immunoglobulin-like) domain. SIMILARITY: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. SIMILARITY: Contains 2 TSP type-1 domains. SIMILARITY: Contains 1 ZU5 domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95185
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
