Human Gene GYPA (ENST00000360771.8) from GENCODE V44
Description: glycophorin A (MNS blood group) (from HGNC GYPA)
RefSeq Summary (NM_002099): Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000360771.8
Gencode Gene: ENSG00000170180.22
Transcript (Including UTRs)
Position: hg38 chr4:144,109,304-144,140,751 Size: 31,448 Total Exon Count: 7 Strand: -
Coding Region
Position: hg38 chr4:144,111,394-144,140,635 Size: 29,242 Coding Exon Count: 7
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Primer design for this transcript
MalaCards Disease Associations
MalaCards Gene Search: GYPA
Diseases sorted by gene-association score: malaria * (226), pyridoxine-responsive sideroblastic anemia (11), fetal erythroblastosis (6), hereditary spherocytosis (6), pneumocystosis (5), carrion's disease (5), autoimmune disease of blood (5), anemia of prematurity (5), myopathy, tubular aggregate, 1 (4), parasitic protozoa infectious disease (1), diamond-blackfan anemia (1), leukemia, acute myeloid (0)* = Manually curated disease association
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
S77893 - GPSAT=glycophorin SAT [human, peripheral bloods, mRNA Partial, 407 nt].L31860 - Human glycophorin A, MN-types (GYPA) mRNA, complete cds.BX649043 - Homo sapiens mRNA; cDNA DKFZp779D1513 (from clone DKFZp779D1513).JD092875 - Sequence 73899 from Patent EP1572962.JD264282 - Sequence 245306 from Patent EP1572962.JD553104 - Sequence 534128 from Patent EP1572962.JD113442 - Sequence 94466 from Patent EP1572962.JD267094 - Sequence 248118 from Patent EP1572962.JD343691 - Sequence 324715 from Patent EP1572962.JD306057 - Sequence 287081 from Patent EP1572962.X51798 - Human mRNA for glycophorin A.JD345179 - Sequence 326203 from Patent EP1572962.JD236723 - Sequence 217747 from Patent EP1572962.JD313628 - Sequence 294652 from Patent EP1572962.BC013328 - Homo sapiens glycophorin A (MNS blood group), mRNA (cDNA clone MGC:13625 IMAGE:4134368), complete cds.BC005319 - Homo sapiens glycophorin A (MNS blood group), mRNA (cDNA clone MGC:12403 IMAGE:3930700), complete cds.JD146654 - Sequence 127678 from Patent EP1572962.X08054 - Human mRNA for erythrocyte membrane glycophorin A.AK290561 - Homo sapiens cDNA FLJ76020 complete cds, highly similar to Homo sapiens glycophorin A (includes MN blood group) (GYPA), mRNA.JD288159 - Sequence 269183 from Patent EP1572962.EU338232 - Homo sapiens clone TW279GA7 glycophorin A (GYPA) mRNA, complete cds, alternatively spliced.EU338234 - Homo sapiens clone AM378GA6 glycophorin A MNS blood group (GYPA) mRNA, complete cds, alternatively spliced.GU347003 - Homo sapiens clone TW280GA15 glycophorin A mRNA, complete cds, alternatively spliced.GU347004 - Homo sapiens clone TW280GA7 glycophorin A mRNA, complete cds, alternatively spliced.EU338231 - Homo sapiens clone TW279GA5 glycophorin A (GYPA) mRNA, complete cds, alternatively spliced.EU338233 - Homo sapiens clone TW279GA9 glycophorin A (GYPA) mRNA, complete cds, alternatively spliced.GU347007 - Homo sapiens clone TW420GA3 glycophorin A mRNA, complete cds, alternatively spliced.GU347005 - Homo sapiens clone AM378GA10 glycophorin A mRNA, complete cds, alternatively spliced.GU347006 - Homo sapiens clone N279GA21 glycophorin A mRNA, partial cds, alternatively spliced.GU347002 - Homo sapiens clone TW279GA13 glycophorin A mRNA, complete cds, alternatively spliced.GU347008 - Homo sapiens clone TW420GA39 glycophorin A mRNA, partial cds, alternatively spliced.X57023 - H.sapiens mRNA for Glycophorin A.DQ893046 - Synthetic construct clone IMAGE:100005676; FLH192982.01X; RZPDo839B0678D glycophorin A (MNS blood group) (GYPA) gene, encodes complete protein.KJ896950 - Synthetic construct Homo sapiens clone ccsbBroadEn_06344 GYPA gene, encodes complete protein.KJ901475 - Synthetic construct Homo sapiens clone ccsbBroadEn_10869 GYPA gene, encodes complete protein.KR710187 - Synthetic construct Homo sapiens clone CCSBHm_00010274 GYPA (GYPA) mRNA, encodes complete protein.KR712233 - Synthetic construct Homo sapiens clone CCSBHm_00900191 GYPA (GYPA) mRNA, encodes complete protein.AY950614 - Homo sapiens glycophorin A Mta variant mRNA, complete cds.U00177 - Homo sapiens glycophorin Erik (GPErik) gene complete cds.U00178 - Homo sapiens glycophorin Erik STA (GPErik) gene complete cds.U00179 - Human glycophorin Erik I-IV (GPErik) mRNA, complete cds.M12857 - Human glycophorin A mRNA.L07251 - Homo sapiens glycophorin Mz II-IV precursor (HGPMz) mRNA, partial cds.L07253 - Homo sapiens glycophorin Mz II-V precursor (HGPMz) mRNA, partial cds.M36281 - Human glycophorin A mRNA, partial cds.JD162955 - Sequence 143979 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04640 - Hematopoietic cell lineage
Other Names for This Gene
Alternate Gene Symbols: A0A0C4DFT7, ENST00000360771.1, ENST00000360771.2, ENST00000360771.3, ENST00000360771.4, ENST00000360771.5, ENST00000360771.6, ENST00000360771.7, L31860, uc003ijo.1, uc003ijo.2, uc003ijo.3, uc003ijo.4, uc003ijo.5UCSC ID: ENST00000360771.8RefSeq Accession: NM_002099
CCDS: CCDS34069.1
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.