Human Gene CARTPT (ENST00000296777.5) from GENCODE V44
Description: Homo sapiens CART prepropeptide (CARTPT), mRNA. (from RefSeq NM_004291) RefSeq Summary (NM_004291): This gene encodes a preproprotein that is proteolytically processed to generate multiple biologically active peptides. These peptides play a role in appetite, energy balance, maintenance of body weight, reward and addiction, and the stress response. Expression of a similar gene transcript in rodents is upregulated following administration of cocaine and amphetamine. Mutations in this gene are associated with susceptibility to obesity in humans. [provided by RefSeq, Feb 2016]. Gencode Transcript: ENST00000296777.5 Gencode Gene: ENSG00000164326.5 Transcript (Including UTRs) Position: hg38 chr5:71,719,275-71,721,045 Size: 1,771 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chr5:71,719,294-71,720,615 Size: 1,322 Coding Exon Count: 3
ID:CART_HUMAN DESCRIPTION: RecName: Full=Cocaine- and amphetamine-regulated transcript protein; Contains: RecName: Full=CART(1-39); Contains: RecName: Full=CART(42-89); Flags: Precursor; FUNCTION: Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. It promotes neuronal development and survival in vitro. INTERACTION: P13688:CEACAM1; NbExp=3; IntAct=EBI-4314526, EBI-4314481; P40199:CEACAM6; NbExp=3; IntAct=EBI-4314526, EBI-4314501; SUBCELLULAR LOCATION: Secreted (Potential). TISSUE SPECIFICITY: Hypothalamus. Found in neurons of the ventrolateral part of the arcuate nucleus, in the external zone of the median eminence, and also found in terminals in the periventricular part of the paraventricular nucleus. INDUCTION: By leptin. SIMILARITY: Belongs to the CART family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q16568
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.