Human Gene CEP120 (ENST00000328236.10) from GENCODE V44
Description: Homo sapiens centrosomal protein 120 (CEP120), transcript variant 1, mRNA. (from RefSeq NM_153223) RefSeq Summary (NM_153223): This gene encodes a protein that functions in the microtubule-dependent coupling of the nucleus and the centrosome. A similar protein in mouse plays a role in both interkinetic nuclear migration, which is a characteristic pattern of nuclear movement in neural progenitors, and in neural progenitor self-renewal. Mutations in this gene are predicted to result in neurogenic defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]. Gencode Transcript: ENST00000328236.10 Gencode Gene: ENSG00000168944.17 Transcript (Including UTRs) Position: hg38 chr5:123,344,895-123,423,558 Size: 78,664 Total Exon Count: 21 Strand: - Coding Region Position: hg38 chr5:123,346,519-123,422,998 Size: 76,480 Coding Exon Count: 20
ID:CE120_HUMAN DESCRIPTION: RecName: Full=Centrosomal protein of 120 kDa; Short=Cep120; AltName: Full=Coiled-coil domain-containing protein 100; FUNCTION: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. May play a role in centriole duplication during mitosis (By similarity). SUBUNIT: Interacts with TACC2 and TACC3 (By similarity). Interacts with CCDC52 (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome (By similarity). Note=Regulates the localization of TACC3 to the centrosome in neural progenitors in vivo (By similarity). SIMILARITY: Belongs to the CEP120 family. SEQUENCE CAUTION: Sequence=BAC04155.1; Type=Erroneous initiation; Sequence=CAH10561.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8N960
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
