Human Gene TTC1 (ENST00000231238.10) from GENCODE V44
Description: Homo sapiens tetratricopeptide repeat domain 1 (TTC1), transcript variant 1, mRNA. (from RefSeq NM_003314) RefSeq Summary (NM_003314): This gene encodes a protein that belongs to the tetratrico peptide repeat superfamily of proteins. The encoded protein plays a role in protein-protein interactions, and binds to the Galpha subunit of G protein-coupled receptors to activate the Ras signaling pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]. Gencode Transcript: ENST00000231238.10 Gencode Gene: ENSG00000113312.12 Transcript (Including UTRs) Position: hg38 chr5:160,009,139-160,065,543 Size: 56,405 Total Exon Count: 8 Strand: + Coding Region Position: hg38 chr5:160,010,529-160,065,065 Size: 54,537 Coding Exon Count: 7
ID:TTC1_HUMAN DESCRIPTION: RecName: Full=Tetratricopeptide repeat protein 1; Short=TPR repeat protein 1; SUBUNIT: Interacts with the GAP domain of NF1. SIMILARITY: Contains 3 TPR repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99614
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
