Human Gene RAB24 (ENST00000393611.6) from GENCODE V44
  Description: May be involved in autophagy-related processes (By similarity). (from UniProt Q969Q5)
RefSeq Summary (NM_130781): RAB24 is a small GTPase of the Rab subfamily of Ras-related proteins that regulate intracellular protein trafficking (Olkkonen et al., 1993 [PubMed 8126105]).[supplied by OMIM, Aug 2009].
Gencode Transcript: ENST00000393611.6
Gencode Gene: ENSG00000169228.14
Transcript (Including UTRs)
   Position: hg38 chr5:177,301,451-177,303,706 Size: 2,256 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg38 chr5:177,301,743-177,303,288 Size: 1,546 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:177,301,451-177,303,706)mRNA (may differ from genome)Protein (203 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
PubMedReactomeUniProtKB

-  Comments and Description Text from UniProtKB
  ID: RAB24_HUMAN
DESCRIPTION: RecName: Full=Ras-related protein Rab-24;
FUNCTION: May be involved in autophagy-related processes (By similarity).
SUBUNIT: Unlike other Rab family members, does not interact with GDP dissociation inhibitors (GDIs), including ARHGDIA and ARHGDIB. Interacts with ZFYVE20.
SUBCELLULAR LOCATION: Cytoplasm, cytosol. Membrane; Lipid-anchor (By similarity). Note=Only about 20-25% is recovered in the particulate fraction.
INDUCTION: By extensive retinoic acid treatment, in Ntera-2 teratoma cell line induced to differentiate into post-mitotic neurons (NTN2) (at protein level).
PTM: Isoprenylation is inefficient compared to other Rab family members.
MISCELLANEOUS: The unusual Ser-67, instead of a conserved Gln in other family members, is the cause of low GTPase activity. As a result, the predominant nucleotide associated with the protein is GTP (By similarity).
SIMILARITY: Belongs to the small GTPase superfamily. Rab family.

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 84.90 RPKM in Whole Blood
Total median expression: 1414.92 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -170.60332-0.514 Picture PostScript Text
3' UTR -109.50292-0.375 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005225 - Small_GTP-bd_dom
IPR001806 - Small_GTPase
IPR003579 - Small_GTPase_Rab_type

Pfam Domains:
PF00071 - Ras family

ModBase Predicted Comparative 3D Structure on Q969Q5
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding

Biological Process:
GO:0006914 autophagy
GO:0015031 protein transport
GO:0043312 neutrophil degranulation

Cellular Component:
GO:0005737 cytoplasm
GO:0005776 autophagosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030667 secretory granule membrane


-  Descriptions from all associated GenBank mRNAs
  LF213791 - JP 2014500723-A/21294: Polycomb-Associated Non-Coding RNAs.
MA449368 - JP 2018138019-A/21294: Polycomb-Associated Non-Coding RNAs.
LF209799 - JP 2014500723-A/17302: Polycomb-Associated Non-Coding RNAs.
MA445376 - JP 2018138019-A/17302: Polycomb-Associated Non-Coding RNAs.
AF087904 - Homo sapiens rab24 mRNA, complete cds.
BC021263 - Homo sapiens RAB24, member RAS oncogene family, mRNA (cDNA clone MGC:29471 IMAGE:4329216), complete cds.
AL833898 - Homo sapiens mRNA; cDNA DKFZp761H152 (from clone DKFZp761H152).
BC010006 - Homo sapiens RAB24, member RAS oncogene family, mRNA (cDNA clone MGC:15055 IMAGE:4300377), complete cds.
BC015534 - Homo sapiens RAB24, member RAS oncogene family, mRNA (cDNA clone MGC:9474 IMAGE:3916832), complete cds.
AK021761 - Homo sapiens cDNA FLJ11699 fis, clone HEMBA1005047, highly similar to RAS-RELATED PROTEIN RAB-24.
AF258583 - Homo sapiens PP4748 mRNA, complete cds.
JD248570 - Sequence 229594 from Patent EP1572962.
JD112666 - Sequence 93690 from Patent EP1572962.
JD396383 - Sequence 377407 from Patent EP1572962.
JD266699 - Sequence 247723 from Patent EP1572962.
JD111017 - Sequence 92041 from Patent EP1572962.
AK308155 - Homo sapiens cDNA, FLJ98103.
JD317787 - Sequence 298811 from Patent EP1572962.
BT007268 - Homo sapiens RAB24, member RAS oncogene family mRNA, complete cds.
DQ891036 - Synthetic construct clone IMAGE:100003666; FLH168721.01X; RZPDo839C0694D RAB24, member RAS oncogene family (RAB24) gene, encodes complete protein.
DQ894215 - Synthetic construct Homo sapiens clone IMAGE:100008675; FLH168717.01L; RZPDo839C0693D RAB24, member RAS oncogene family (RAB24) gene, encodes complete protein.
EU831626 - Synthetic construct Homo sapiens clone HAIB:100066655; DKFZo007D1119 RAB24, member RAS oncogene family protein (RAB24) gene, encodes complete protein.
EU831711 - Synthetic construct Homo sapiens clone HAIB:100066740; DKFZo003D1120 RAB24, member RAS oncogene family protein (RAB24) gene, encodes complete protein.
JD448781 - Sequence 429805 from Patent EP1572962.
JD316968 - Sequence 297992 from Patent EP1572962.
JD356823 - Sequence 337847 from Patent EP1572962.
JD557140 - Sequence 538164 from Patent EP1572962.
JD563083 - Sequence 544107 from Patent EP1572962.
JD394536 - Sequence 375560 from Patent EP1572962.
JD345301 - Sequence 326325 from Patent EP1572962.
JD450271 - Sequence 431295 from Patent EP1572962.
JD229091 - Sequence 210115 from Patent EP1572962.
LF331750 - JP 2014500723-A/139253: Polycomb-Associated Non-Coding RNAs.
MA567327 - JP 2018138019-A/139253: Polycomb-Associated Non-Coding RNAs.
JD058131 - Sequence 39155 from Patent EP1572962.
JD404593 - Sequence 385617 from Patent EP1572962.
JD408863 - Sequence 389887 from Patent EP1572962.
JD072752 - Sequence 53776 from Patent EP1572962.
JD141656 - Sequence 122680 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q969Q5 (Reactome details) participates in the following event(s):

R-HSA-6798743 Exocytosis of secretory granule membrane proteins
R-HSA-8870466 RGGT:CHM binds RABs
R-HSA-8870469 RGGT geranylgeranylates RAB proteins
R-HSA-6798695 Neutrophil degranulation
R-HSA-168249 Innate Immune System
R-HSA-8873719 RAB geranylgeranylation
R-HSA-168256 Immune System
R-HSA-597592 Post-translational protein modification
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: BC015534, ENST00000393611.1, ENST00000393611.2, ENST00000393611.3, ENST00000393611.4, ENST00000393611.5, Q7Z4Z7, Q969Q5, RAB24_HUMAN, uc003mfv.1, uc003mfv.2, uc003mfv.3, uc003mfv.4, uc003mfv.5
UCSC ID: ENST00000393611.6
RefSeq Accession: NM_130781
Protein: Q969Q5 (aka RAB24_HUMAN or RB24_HUMAN)
CCDS: CCDS34300.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.