Human Gene MAML1 (ENST00000292599.4) from GENCODE V44
Description: Homo sapiens mastermind like transcriptional coactivator 1 (MAML1), mRNA. (from RefSeq NM_014757) RefSeq Summary (NM_014757): This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000292599.4 Gencode Gene: ENSG00000161021.13 Transcript (Including UTRs) Position: hg38 chr5:179,732,822-179,777,283 Size: 44,462 Total Exon Count: 5 Strand: + Coding Region Position: hg38 chr5:179,733,113-179,774,877 Size: 41,765 Coding Exon Count: 5
ID:MAML1_HUMAN DESCRIPTION: RecName: Full=Mastermind-like protein 1; Short=Mam-1; FUNCTION: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. SUBUNIT: Interacts (via N-terminus) with NOTCH1, NOTCH2, NOTCH3 and NOTCH4 (via ankyrin repeat region). Interacts (via N-terminus) with p53 (via DNA-binding region). Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1. Also binds CREBBP/CBP and CDK8. SUBCELLULAR LOCATION: Nucleus speckle. Note=Nuclear, in a punctate manner. TISSUE SPECIFICITY: Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen. DOMAIN: The C-terminal region is required for transcriptional activation. SIMILARITY: Belongs to the mastermind family. SEQUENCE CAUTION: Sequence=BAA12114.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q92585
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
