Human Gene RXRB (ENST00000374680.4) from GENCODE V44
Description: Homo sapiens retinoid X receptor beta (RXRB), transcript variant 2, mRNA. (from RefSeq NM_021976) RefSeq Summary (NM_021976): This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]. Gencode Transcript: ENST00000374680.4 Gencode Gene: ENSG00000204231.11 Transcript (Including UTRs) Position: hg38 chr6:33,193,588-33,200,665 Size: 7,078 Total Exon Count: 10 Strand: - Coding Region Position: hg38 chr6:33,194,682-33,200,476 Size: 5,795 Coding Exon Count: 10
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00104 - Ligand-binding domain of nuclear hormone receptor PF00105 - Zinc finger, C4 type (two domains)
ModBase Predicted Comparative 3D Structure on Q5STP9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003707 steroid hormone receptor activity GO:0008270 zinc ion binding GO:0043565 sequence-specific DNA binding GO:0046872 metal ion binding
X63523 - H.sapiens mRNA DAUDI6 3'-region. BC001167 - Homo sapiens retinoid X receptor, beta, mRNA (cDNA clone MGC:1831 IMAGE:3502936), complete cds. X65463 - H.sapiens mRNA for MHC class I promoter binding protein. JD143222 - Sequence 124246 from Patent EP1572962. JD066308 - Sequence 47332 from Patent EP1572962. JD222767 - Sequence 203791 from Patent EP1572962. JD437617 - Sequence 418641 from Patent EP1572962. JD192874 - Sequence 173898 from Patent EP1572962. JD563091 - Sequence 544115 from Patent EP1572962. JD166344 - Sequence 147368 from Patent EP1572962. JD394364 - Sequence 375388 from Patent EP1572962. JD520110 - Sequence 501134 from Patent EP1572962. JD470121 - Sequence 451145 from Patent EP1572962. JD135072 - Sequence 116096 from Patent EP1572962. JD545226 - Sequence 526250 from Patent EP1572962. JD455780 - Sequence 436804 from Patent EP1572962. JD168325 - Sequence 149349 from Patent EP1572962. JD530504 - Sequence 511528 from Patent EP1572962. JD080345 - Sequence 61369 from Patent EP1572962. JD516917 - Sequence 497941 from Patent EP1572962. JD318183 - Sequence 299207 from Patent EP1572962. JD123571 - Sequence 104595 from Patent EP1572962. JD530186 - Sequence 511210 from Patent EP1572962. JD252767 - Sequence 233791 from Patent EP1572962. JD261860 - Sequence 242884 from Patent EP1572962. JD518358 - Sequence 499382 from Patent EP1572962. JD431684 - Sequence 412708 from Patent EP1572962. JD309559 - Sequence 290583 from Patent EP1572962. JD450670 - Sequence 431694 from Patent EP1572962. JD524458 - Sequence 505482 from Patent EP1572962. X63522 - H.sapiens mRNA DAUDI6 for retinoic acid X receptor b. AK225842 - Homo sapiens mRNA for retinoid X receptor, beta variant, clone: FCC126E12. AK302125 - Homo sapiens cDNA FLJ61673 complete cds, highly similar to Retinoic acid receptor RXR-beta. AB209244 - Homo sapiens mRNA for retinoid X receptor, beta variant protein. M84820 - Human retinoid X receptor beta (RXR-beta) mRNA, complete cds. HQ692844 - Homo sapiens retinoid X nuclear receptor beta (NR2B2) mRNA, complete cds. HQ709179 - Homo sapiens retinoid X nuclear receptor beta (NR2B2) mRNA, complete cds. KJ897510 - Synthetic construct Homo sapiens clone ccsbBroadEn_06904 RXRB gene, encodes complete protein. BT007280 - Homo sapiens retinoid X receptor, beta mRNA, complete cds. KU178313 - Homo sapiens retinoid X receptor beta isoform 1 (RXRB) mRNA, partial cds, alternatively spliced. KU178314 - Homo sapiens retinoid X receptor beta isoform 2 (RXRB) mRNA, partial cds, alternatively spliced. KU178315 - Homo sapiens retinoid X receptor beta isoform 3 (RXRB) mRNA, partial cds, alternatively spliced. KU178316 - Homo sapiens retinoid X receptor beta isoform 4 (RXRB) mRNA, complete cds, alternatively spliced. AB384890 - Synthetic construct DNA, clone: pF1KB4058, Homo sapiens RXRB gene for retinoic acid receptor RXR-beta, complete cds, without stop codon, in Flexi system. JD025404 - Sequence 6428 from Patent EP1572962. JD033197 - Sequence 14221 from Patent EP1572962. AK301096 - Homo sapiens cDNA FLJ50703 complete cds, highly similar to Retinoic acid receptor RXR-beta. X66424 - H.sapiens mRNA for retinoid X receptor b, exons a and b. AK295759 - Homo sapiens cDNA FLJ50538 complete cds, highly similar to Retinoic acid receptor RXR-beta. AK300402 - Homo sapiens cDNA FLJ61401 complete cds, highly similar to Retinoic acid receptor RXR-beta.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa03320 - PPAR signaling pathway hsa04920 - Adipocytokine signaling pathway hsa05200 - Pathways in cancer hsa05216 - Thyroid cancer hsa05222 - Small cell lung cancer hsa05223 - Non-small cell lung cancer