Human Gene FBXL4 (ENST00000369244.7) from GENCODE V44
Description: Homo sapiens F-box and leucine rich repeat protein 4 (FBXL4), transcript variant 3, non-coding RNA. (from RefSeq NR_103836) RefSeq Summary (NM_001278716): This gene encodes a member of the F-box protein family, which are characterized by an approximately 40 amino acid motif, the F-box. F-box proteins constitute one subunit of modular E3 ubiquitin ligase complexes, called SCF complexes, which function in phosphorylation-dependent ubiquitination. The F-box domain mediates protein-protein interactions and binds directly to S-phase kinase-associated protein 1. In addition to an F-box domain, the encoded protein contains at least 9 tandem leucine-rich repeats. The ubiquitin ligase complex containing the encoded protein may function in cell-cycle control by regulating levels of lysine-specific demethylase 4A. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]. Gencode Transcript: ENST00000369244.7 Gencode Gene: ENSG00000112234.9 Transcript (Including UTRs) Position: hg38 chr6:98,868,535-98,947,946 Size: 79,412 Total Exon Count: 10 Strand: - Coding Region Position: hg38 chr6:98,874,278-98,926,988 Size: 52,711 Coding Exon Count: 7
ID:FBXL4_HUMAN DESCRIPTION: RecName: Full=F-box/LRR-repeat protein 4; AltName: Full=F-box and leucine-rich repeat protein 4; AltName: Full=F-box protein FBL4/FBL5; SUBUNIT: Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. TISSUE SPECIFICITY: Expressed in heart, kidney, liver, lung, pancreas, and placenta, but not in skeletal muscle. SIMILARITY: Contains 1 F-box domain. SIMILARITY: Contains 9 LRR (leucine-rich) repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UKA2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000209 protein polyubiquitination GO:0006511 ubiquitin-dependent protein catabolic process GO:0043687 post-translational protein modification